Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

Nikolskaya IA, Kopetskiy IS, Volkov AG, Dikopova NJ, Nosov VV

Currently actively conducted research on the application of various biomaterials and the development of special methods of influence on the tissues allow in complex in the treatment process to influence on the metabolic and regenerative processes in the pulp tissues. Improving the quality of the treatment of reversible pulpitis by application of ozone therapy in combination with the method of direct pulp capping with materials based on calcium hydroxide is aimed at preserving the viability and stimulation of the regenerative function of tooth pulp.

Received: 2013-09-18

Published online: 2017-01-05

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Kruglikov GG, Suslov VB, Likhacheva LM, Stranzha NB, Oettinger AP

In the conditions of inflammation and hypoxia the destructive processes are noted in all cells of the air-blood barrier, basement membranes and in the interstitium. The basis of pathological processes in cells with short and long lives cycles are violations of the energy metabolism in mitochondria. Structural and functional characteristics of long-living cells promote the greater resistance to oxygen deficiency. The increase in the number of poikilocytes among red blood cells in the alveolar capillaries may serve as an indicator of local hypoxia.

Received: 2013-07-02

Published online: 2017-01-05

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Pogodin PV, Lagunin AA, Ivanov SM, Konova VI, Filimonov DA, Poroykov VV

The purpose of the study is development of a specialized version of the computer system PASS — PASS Targets for computer-aided prediction of the spectra of interactions between chemical compounds and protein-targets based on ChEMBLdb database (14 version). Data on the interaction between 348 137 different compounds and protein-targets were extracted from ChEMBLdb and were used for PASS training. The average prediction accuracy calculated by leave-one-out cross-validation procedure is 98.1 %. The developed copputer system PASS Targets and be used to predict interaction with 3257 protein-targets representing eight major classes of protein-targets of 215 species.

Received: 2013-07-01

Published online: 2017-01-05

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Dyakonova IN, Rakhmanova IV, Burmistrova DS, Ishanova YuS

In our research, using two electrophysiological methods (registration of auditory brainstem response, distortion product otoacoustic emission) we were estimating auditory function of immature rabbits in response of introduction of therapeutic doses of vancomycin (15 mg/kg daily, 7 days). Damaging action was reflected in a functional condition of peripheral department of the acoustic analyzer. According to the brainstem auditory evoked potentials it expressed in elevation of thresholds of the first peak of ABR and shortening of peripheral time of carrying out. According to distortion product otoacoustic emission — a decreased amplitude caused the acoustic answer to frequency of 4 kHz and change of speed of maturing of functioning of outer hair cells on frequencies of 2, 4, 6 kHz.

Received: 2013-09-23

Published online: 2017-01-05

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Polunin VS

Abstract has not been added yet...

Received: 2013-11-11

Published online: 2017-01-05

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Adeishvili PS, Shamsheva OV, Polesko IV, Osipov GA

Mass spectrometry of microbial markers was used to study the microbial landscape of the oropharynx in 22 children with infectious mononucleosis aged from 3 to 14 years. The comparison group consisted of 10 children without clinical signs of infectious mononucleosis and acute respiratory viral infections including mucosal and tonsils hyperemia. The data obtained helped to verify and quantify the composition of the microbial community in the oropharynx in infectious mononucleosis and treat angina in infectious mononucleosis as a disease with the association of various opportunistic pathogens that exceeded the number of microbes in healthy children at least more than twice.

Received: 2013-03-20

Published online: 2017-01-05

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Bogomilsky MR, Radtsig EYu, Degtyareva DV

Objective methods of research are widely used for the diagnosis of various origins dysphonia. Over the last decades there has been a steady increase in the number of children with these conditions. Acoustic analysis provides the basic data for the evaluation of voice. This study can be used as a screening method to identify the pathology of the larynx. Acoustic voice analysis data are irreplaceable in the differential diagnosis of various diseases, as well as in monitoring the quality of the treatment.

Received: 2013-04-22

Published online: 2017-01-05

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Sapozhnikov YaM, Minasyan VS, Mkhitaryan AS

On the basis of the examination of 264 children aged from 1 to 3 years after the acute otitis media, the survey algorithm was developed with the use of modern audiological and endoscopic equipment. It allows timely and accurately to determine the causes leading to the acute otitis media and hearing loss associated with the pathology of nasophariynx. It makes it possible to choose the optimum treatment regimen in each particular case, eliminating further development of persistent hearing loss and to minimize the need for bypass surgery of the tympanic cavity, and to ensure the harmonious speech development of a child.

Received: 2013-03-11

Published online: 2017-01-05

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