Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Nikolskaya IA, Kopetskiy IS, Dubovaya TK, Vygorko VF, Volkov AG

In the study there was worked out a set of measures aimed at preserving the vitality and regeneration of dental pulp in an experiment on rabbits. It is given a comparative analysis of the characteristics of therapeutic pads based on hydroxyapatite ultrahigh dispersion and calcium hydroxide and their use in combination with a physiotherapeutic method of treatment — ozone therapy. These procedures were directed on increasing the protection of the pulp from external influences and created conditions for the invertibility of inflammation and regeneration. These pilot studies allow the development of new measures aimed at preserving the vitality of the tooth pulp and to achieve sustainable results in the treatment of patients in clinical practice.

Received: 2012-04-17

Published online: 2017-01-05

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VIEWS 4606

Askanidi IP, Pyshkina LI, Serguladze TN

The article contains modern data review of a brain perfusion on extra- and intracranial levels during occlusion diseases of brachiocephalic arteries. In patients with brain ischemia there were described the possibilities of assessing the level of perfusion by noninvasive methods: single-proton emission computed tomography with <sup>99m</sup>Tc-HMPAO and ultrasound diagnostic methods with functional loading tests.

Received: 2012-04-18

Published online: 2017-01-05

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VIEWS 4677

Panova OV, Stakhanov VA, Stenina MA, Voevodin DA, Krivov LI

The aim of the study was to evaluate the clinical features of the course of tuberculosis in infants and preschool children against herpes infection. The presence of viral infection was noted on detection of DNA viruses: the Epstein-Barr virus, herpes simplex virus type VI, cytomegalovirus in blood mononuclear cells of children. According to the results of PCR diagnosis, 28 (the 1st group) of the 61 children surveyed were infected with herpes viruses, 33 children (the 2nd group) — were not infected with those viruses. The frequency of comorbidity was higher in the 1st group. 12 of 14 children diagnosed with tuberculosis intoxication were infected with herpes viruses. Tuberculosis intoxication in the structure of the clinical forms of tuberculosis in the 1st group was 43 %, and in the 2nd group was only 6 %. The role of viral suppression of dendritic cells as a possible factor in the suppression of specific immune response to Mycobacterium tuberculosis in the mediastinal lymph nodes and the emergence of "minor" forms of tuberculosis in children was discussed.

Received: 2012-04-18

Published online: 2017-01-05

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VIEWS 4748

Nazarenko GI, Darenkov SP, Zyryanova ON, Sakrisyan AD

The article is devoted to modern techniques of surgical treatment of Peyronie's disease. To date, surgery is the main effective means of therapy of this symptomatic disease. There is proposed a set of techniques that can be divided into two groups of operations: shortening (Nesbit operation and its modifications, plication) and lengthening (patchwork) corporoplasty. Shortening techniques proved to be effective, and subjected to certain indications for their use, are considered satisfactory by professionals and patients. Among them the most preferred are modified Nesbit operations. When prolonging corporoplasty today probably there is no need for complete excision of the plaque, and the most contentious issue is the selection of optimal plastic automaterial. The author presented a case of his own experience of surgical treatment of Peyronie's disease symptom.

Received: 2012-04-04

Published online: 2017-01-05

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VIEWS 4889

Kovalchuk LV, Gankovskaya LV, Rakhmanova IV, Svitich OA, Zinker GM, Gankovskiy VA, Kartashov DD, Volkova YuV, Russanova KV

The results of the study of the effectiveness of personalized immunotherapy in children with hypertrophy of II–III degree adenoid vegetations are presented in the article. It was established, that application of autologous complex of immunopeptides including cytokines and antimicrobial peptides produced by white blood cells of the patients, led to the normalization of nasal breathing, a reduction in the frequency of otitis and of respiratory viral infections at 6 months observation after the treatment. There were identified individual differences in gene expression of molecules of the innate immunity in the mucosa of the nasal cavity, what provides the personalized approach to immunotherapy.

Received: 2012-04-17

Published online: 2017-01-05

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VIEWS 5003

Mikhaylova SD, Semushkina TM, Sokolov AV, Mikaelyan NP, Storozhakov GI

In the acute experiments on rabbits there was discovered an impulse activity of afferent and interneurons of the medullar cardiovascular center in the conditions of hypoxia and hypercapnia. Afferent neurons received information on myelinated fibers of vagus nerve and caused reaction on hypercapnia in one per three cases. Interneurons received information simultaneously on both myelinated and unmyelinated fibers of vagus nerves. They reacted both on hypoxia and hypercapnia.

Received: 2012-01-30

Published online: 2017-01-05

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VIEWS 4754

Konstantinova NA, Kulikova IYu, Karandashov EN

The temperature dependence of the electrophoretic mobility of erythrocytes loaded with cryoglobulins, isolated from serum of patients with various diseases and different forms of a disease (systemic lupus erythematosus, chronic glomerulonephritis, atherothrombotic and cardioembolic ischemic stroke options) was investigated. Erythrocytes were obtained from healthy donors' blood. It was established that cryoglobulins significantly changed electrophoretic mobility of erythrocytes. This change may be in different directions: both upward and downward, depending on the nature of the disease and forms of its manifestation. It was shown that cryoglobulins complexes decompose at elevated temperatures. It was concluded that the electrophoretic method for estimating cryocomplexes is quite informative, in particular, to assess the extent of their heterogeneity.

Received: 2012-04-17

Published online: 2017-01-05

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Comments 0

VIEWS 4568

Ilyenko LI, Guzhvina EN, Tumanova EI

The article deals with the experimental data on the effect of the antihomotoxic preparation «Traumeel S» on the structure and function of the placenta in physiological conditions and in case of chronic hypoxia. The experiments were performed on 60 laboratory non-stock female rats, divided into four groups. The first group (n = 10) served as a control one. Animals in group 2 (n = 20) were subjected to hypoxia from the 10th to the 22nd day of gestation, at the same time receiving «Traumeel S» of 0.2–0.3 ml intramuscular injection every other day. Animals of group 3 (n = 20) were subjected to hypoxia, but they did not receive the preparation. The 4th group of rats (n = 10) received the preparation but was not exposed to hypoxia. On the 22nd–23rd day of pregnancy there was undertaken euthanasia to the rats and then histological examination of placentas was performed. The use of «Traumeel S» during pregnancy on the phone of hypoxia has a positive effect on the formation of the placenta, it stimulates the development of compensatory-adaptive processes in it.

Received: 2012-04-10

Published online: 2017-01-05

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VIEWS 4715