Original research Investigation of mechanisms of sensibilization of tumor cells by new synthetic progestin buterol
Odintsova EV, Fedotcheva TA, Banin VV, Shimanovsky NL
One of the most frequent problems in the chemotherapy of hormone dependent tumors is the development of resistance in tumor cells to cytostatics. The main role among possible mechanisms of such resistance plays overexpression of P-glycoprotein, MRP and BCRP — the ABC-transporters family proteins, and Bcl-2 — antiapoptotic protein. In this study new synthetic analog of progesterone — buterol — was investigated as a perspective sensibilizing compound, e.g. compound, which increases sensitivity to anticancer drugs. It was shown, that buterol strengthens cytostatic effect of doxorubicin and etoposid in breast cancer cells in vitro. Also it was demonstrated that buterol decreases BCRP, P-glycoprotein and MRP mRNA expression in common on the 10th day of incubation. Besides, buterol suppresses mRNA expression of Bcl-2. Thus mechanisms of sensitization in MCF-7 cells are associated with the decrease of transporter proteins expression and antiapoptotic Bcl-2 protein expression.
Received: 2011-12-07
Published online: 2017-01-05
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VIEWS 4727
Miscellaneous To the problem of system forming factors of modern university education
Morgun AN
The aim of this research is the rationalization of the innovation system-factor of modern university education. The analysis of the present situation in university's education was conducted in terms of trends in the continuum of individualism-corporatism. A trend to the atomization of interests was shown as the main motivational factors of modern education, the entropic dynamic character of resource development was shown, the lack of their consolidating component. The characteristics of the necessary system-factor were given.
Received: 2011-12-19
Published online: 2017-01-05
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VIEWS 4651
Editorial To the 80th anniversary of Yury Andreevich Vladimirov
Abstract has not been added yet...
Received: 2011-12-19
Published online: 2017-01-05
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VIEWS 2736
Original research The efficacy of systemic enzyme therapy in the complex treatment of trophic ulcers of venous etiology
Vasilev IM, Bogdanec LI, Shcherbin SV
The current strategy for the treatment of venous trophic ulcers (VTU) suggests differentiated approach and a combination of conservative and surgical methods. This paper presents the results of the study of efficacy of systemic enzyme therapy (Phlogenzym by Mucos Pharma, Germany) in patients with varicose veins of lower extremities (CEAP class C6) and stage I, II and III VTU. The study included 38 patients aged 12 to 82 years. The patients were divided into the experimental (n = 20) and the control (n = 18) groups. The treatment lasted 1 month. Silcofix Professional wound dressings (Pharmaplast, Egypt) were used. All patients received Detralex (Les Laboratoires Servier, France) and wore class 2 and 3 knee-high compression socks. Patients of the experimental group also received Phlogenzym for 30 days (3 tablets 3 times a day). Total ulcer epithelization was observed in 8 (40 %) patients by week 3, and in 18 (90 %) patients by the end of treatment compared to 4 (22 %) and 9 (50 %) patients in the control group, respectively. In the control group, the regenerative process in the area of the ulcerous defect was less prominent compared to the experimental group. Immunoassays revealed a significant reduction in CD4<sup>+</sup>CD25<sup>Bright</sup> cells and increased levels of CD4<sup>+</sup>CD45RO<sup>+</sup> T-lymphocytes in the experimental group, corresponding with the observed positive clinical response. The use of immunomodulatory drug Phlogenzym contributed to a more rapid regression of clinical symptoms of chronic venous insufficiency and faster healing of stage I–III venous trophic ulcers.
Received: 2016-10-24
Published online: 2017-01-05
DOI: 10.24075/brsmu.2016-05-06
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VIEWS 6072
Original research A comparison of gender differences in clinical and angiographic characteristics in young adults with myocardial infarction
Balaian NM, Shebzukhova MM, Grachev NS, Muradianc AA, Shostak NA
The article presents the analysis of clinical and angiographic characteristics and risk factors of myocardial infarction (MI) in men and women aged <45 years. The study included 35 patients with acute MI (15 females, 20 males) of the 14th Department of Cardiology, N. I. Pirogov City Clinical Hospital No. 1 (Moscow). The average age of female and male patients was 41.2 and 39.6 years, respectively. The majority of patients of both sexes had ST-elevation MI (STEMI) (88.6 %), among which Q-wave MI accounted for 60.0 % of cases and typical MI accounted for 71.4 % of cases. Forty percent of patients of both sexes had no previous history of CHD. Almost all risk factors (dyslipidemia, hypertension, early family history etc.) were seen more often in women compared to men, except smoking which was found to be a risk factor in 55 % of men vs. 6 % of women (p <0.05). The coronary angiography data showed the prevalence of the right type of coronary circulation (70 % of patients) and single-vessel disease (80 %) with coronary stenosis of more than 75 %. The time to diagnosis was 2.1 times greater in women than in men accounting for an average of 9.2 and 4.3 hours, respectively. The main causes of delayed MI diagnosis before admittance were late patient referral or diagnostic errors.
Received: 2016-06-23
Published online: 2017-01-05
DOI: 10.24075/brsmu.2016-05-07
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VIEWS 5234
Original research Treatment and rehabilitation of children with electrothermal injury
Rubtsov VV, Tsap NA, Shtukaturov AK
Electrothermal lesions are most often seen in pediatric injuries. This type of injury is uncommon, but is one of the leading causes of death and disability in children. Using medical records, we analyzed the outcomes of the treatment and rehabilitation of children with electrothermal lesions (n = 51) admitted to Pediatric Burn Center, Children’s City Clinical Hospital No. 9 (Yekaterinburg, Russia) over the period from 2010 to 2015. The patients were divided into two groups: group 1 (39 children) had injuries from electrical household appliances and group 2 (12 children) sustained high-voltage injuries. Primary surgical debridement was performed on all children; the extent and depth of the burns were established. The next step of surgical treatment for Group 1 included necrectomy and single-stage dermatoplasty; in group 2 necrectomy and the first stage of skin grafting (formation of a skin flap) were performed. Subsequently, all patients in group 2 received skin grafts for final closure of the skin defect. The duration of treatment in group 2 was 2 times longer than in group 1, due to larger burn areas (an average of 12 % vs. >5 %), longer burn shock (>24 h vs. 10 h), higher complication rate, and multiple stages of surgical treatment. Six patients from group 2 received surgical amputation. However, the division into groups according to the physical properties of the electric current can be beneficial for the development of more effective treatment algorithms.
Received: 2016-06-10
Published online: 2017-01-05
DOI: 10.24075/brsmu.2016-05-08
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VIEWS 4740
Opinion The hypothesis of tissue-specific action of diphtheria toxin
Aleshin AV
Diphtheria is an infection caused by toxigenic strains of Corynebacterium diphtheriae. The pathogen releases the toxin that affects heart, kidneys, adrenal gland, as well as spinal and cerebral nerves. Tissue- and organ-specific action of diphtheria toxin is considered to be associated with the blood supply to these organs. We propose the hypothesis that takes into account the physical and chemical properties of the toxin molecule (positively charged R-domain in the B subunit) and cell expression of different types of the HB-EGF receptor and CD9 co-receptor, which are responsible for the toxin penetration into the cell. The proposed hypothesis explains the possible mechanisms of diphtheria complications.
Received: 2016-06-26
Published online: 2017-01-05
DOI: 10.24075/brsmu.2016-05-09
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VIEWS 5191
History of medicine Medical biophysics: the role of the Department of general and medical biophysics in its formation and development
Vladimirov YuA, Osipov AN, Teselkin YuO
The paper analyzes the results of investigations obtained in different years at the Department of general and medical biophysics of medical-biological faculty of the Russian National Research Medical University named after N. I. Pirogov. The role of lipid peroxidation in the mechanisms of cell damage is estimated. The prospects for the use of chemiluminescence method for the decision of scientific and clinical problems are discussed.
Received: 2012-05-14
Published online: 2017-01-05
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VIEWS 4686