Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

Larina VN, Bart BYa, Golovko MG, Dergunova EN, Mamtsev BN

The aim of this study was to identify the factors negatively affecting the course of chronic heart failure (CHF) and prognosis in elderly patients having been observed in the polyclinic. Data were collected on 248 patients aged 60 to 85 years with CHF II–IV FC NYHA due to ischemic heart disease or hypertension. During the period over two years there were hospitalized 191 (77 %) patients. There were detected independent risk factors for hospitalization of elderly patients with heart failure and low adherence to treatment, as well as predictors of their development. It was shown that low therapy adherence was associated with non-severe chronic heart failure, preserved left ventricular ejection fraction and low level of a patient's education.

Received: 2012-07-02

Published online: 2017-01-05

DOI:

Comments 0

Vartanyan EA, Dergunova EN, Bart BYa, Larina VN, Skakova TI

The research objective was to analyze a structurally functional condition of the right ventricle of patients with chronic heart failure. All 57 patients underwent an echocardiography. The received results allow to draw a conclusion that structural and functional processes of remodeling of the right ventricle with its global dysfunction, accrue with an overload of a small circle of blood circulation: from passive venous post-capillary pulmonary hypertension up to the development of jet hypertension against high pulmonary vascular resistance.

Received: 2012-07-02

Published online: 2017-01-05

DOI:

Comments 0

Larina VN, Runikhina NK, Mikhaylusova MP, Benevskaya VF, Sharashkina NV

The aim of the study was to examine the cognitive status in postmenopausal women with arterial hypertension observed in outpatient settings. 58 women from 44 to 88 years old with arterial hypertension were under study. It was shown that cognitive impairments were found in 40.8 % of women with hypertension during the menopause. It was found that early age at menopause, the presence of depressive status, obesity, changes in the structural-functional state of the left heart and metabolic disorders were associated with decreased cognitive function in women with hypertension.

Received: 2012-07-02

Published online: 2017-01-05

DOI:

Comments 0

Brodskiy MS, Solovyev SS, Golovko MG

Objective determination of the stage of the disease and the severity of chronic obstructive pulmonary disease (COPD) is necessary for selecting the appropriate therapy, and should be taken into account, beside the existing degree of bronchial obstruction, the current level of patient's symptoms, exacerbation risk, and the presence of comorbidities. Modified British Medical Research Council (MRC) questionnaire and the COPD Assessment Test (CAT) validated to assess symptoms in patients with COPD may be used as a part of the comprehensive criteria of severity, as well as used in medical practice to determine the effectiveness of pharmacotherapy.

Received: 2012-07-02

Published online: 2017-01-05

DOI:

Comments 0

Tsitsiashvili MSh, Gubaydullin RR, Bagdatyev VE, Yakubov TJ

In this research we analyzed the changes in intra-abdominal pressure in 38 patients with local (17 patients) and generalized peritonitis (21 patients). The study found significantly higher intra-abdominal pressure in patients with advanced peritonitis than in patients with local peritonitis. In 53 % of patients with local peritonitis intra-abdominal pressure was not observed, and 47 % of patients had its I degree. In the group of generalized peritonitis all patients had intra-abdominal hypertension: I degree was observed in 17.4 % of patients, II degree — in 65.2 %, III degree — in 8.7 % and IV degree — in 8.7 % of patients.

Received: 2012-06-05

Published online: 2017-01-05

DOI:

Comments 0

Vlasov AP, Shibitov VA, Vasilyev VV, Anaskin SG, Vlasov PA, Potyanova IV

The research of laboratory and clinical effects of a new antihypoxant at an acute peritonitis with an accent on studying modifications of lipid metabolism, lipid peroxidation activity and phospholipase A2, some indicators of endogenous intoxication and hypoxia was held. There were analyzed the results of the treatment of 65 patients with acute peritonitis of an appendiceal genesis. The antihypoxant was included in the complex therapy of the patients of the basic group in the early postoperative period. Preparation application led to fast positive clinical and laboratory dynamics and improved the results of the treatment. The major effect of the antihypoxant was in the reduction of the severity of endogenous intoxication by rising detoxication abilities of an organism and decreasing of membrane destructive processes due to reduction of lipid peroxidation and the hypoxia phenomena.

Received: 2012-06-01

Published online: 2017-01-05

DOI:

Comments 0

Skoroglyadov AV, Naumenko MV, Zinchenko AV, Korobushkin GV

The paper presents a review of literature and the stored experience of the Department of traumatology, orthopedics and battle-field surgery of RNRMU named after N. I. Pirogov in diagnostics and treatment of osteochondral fractures of the talus as one of the main reasons for chronic pain in an ankle joint in people of efficient age.

Received: 2012-04-09

Published online: 2017-01-05

DOI:

Comments 0

Volkova EV, Lysyuk EYu, Djokhadze LS, Makarov OV

The aim of our study was to examine changes in levels of vascular growth factors in pregnant women with chronic hypertension (CH). There was carried out a clinical analysis of pregnancy, childbirth, postpartum and postnatal outcomes in 69 pregnant women with CH and 49 women with physiological course of pregnancy. The levels of proangiogenic (PlGF) and antiangiogenic (sFlt-1, sEng) factors in the serum of 28–34 weeks' gestation were investigated in all pregnant women with immune-enzyme analysis. At pregnancy with the CH there was observed an increase in the concentration of antiangiogenic proteins sFlt-1 to 5573 ± 774 pg/ml (3299 ± 544 pg/ml in control, p < 0.05) and endoglin to 7.1 ± 0.8 ng/ml (control 5.4 ± 0.4 ng/ml, p < 0.05). At the same time there was a decrease of proangiogenic PlGF (155.8 ± 30.4 pg/ml vs 238.5 ± 66.1 pg/ml in controls, p < 0.05).

Received: 2012-03-27

Published online: 2017-01-05

DOI:

Comments 0