OPINION

The potential of using the bioluminescent system of Chaetopterus variopedatus to study ferroptosis in living organisms

About authors

1 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Aleksandr S. Shcheglov
Miklouho-Maclay, 16/10, Moscow, 117997; ur.liam@trakuj

About paper

Funding: the study was supported by the Russian Science Foundation (Project 18-74-10102).

Acknowledgements: the authors thank the Center for Precision Genome Editing and Genetic Technologies for Biomedicine (Moscow) for their help.

Author contribution: Shcheglov AS — study conception, literature analysis, manuscript preparation; Tsarkova AS — literature analysis, manuscript preparation.

Received: 2021-05-05 Accepted: 2021-05-12 Published online: 2021-05-30
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  1. Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death Cell Research 2019, 29: 347–64, DOI: 10.1038/s41422-019-0164-5.
  2. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972; 26 (4): 239–57. DOI: 10.1038/bjc.1972.33.
  3. Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 2003; 3: 285–96. DOI: 10.1016/S1535-6108(03)00050-3.
  4. Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ., Yang WS, Fridman DJ, et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007; 447: 864–8. DOI: 10.1038/nature05859.
  5. Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008; 15: 234–45. DOI: 10.1016/j.chembiol.2008.02.010.
  6. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012; 149: 1060–72. DOI: 10.1016/j.cell.2012.03.042.
  7. Angeli JPF, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014; 16: 1180– 91. DOI: 10.1038/ncb3064.
  8. Li J, Cao F, Yin H-l, Huang Z-j, Lin Z-t, Mao N, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020; 11 (2): 88. DOI: 10.1038/s41419-020-2298-2.
  9. Yan H-F, Zou T, Tuo Q-Z, Xu S, Li H, Belaidi AA, et al. Ferroptosis: mechanisms and links with diseases. Signal Transduct Target Ther. 2021; 6 (1): 49. DOI:10.1038/s41392-020-00428-9.
  10. Syed AJ, Anderson JC. Applications of bioluminescence in biotechnology and beyond. Chem Soc Rev. 2021 Mar 18. DOI: 10.1039/d0cs01492c.
  11. Oba Y, Stevani CV, Oliveira AG, Tsarkova AS, Chepurnykh TV, Yampolsky IV. Selected least studied but not forgotten bioluminescent systems. Photochem Photobiol. 2017; 93 (2): 405–15. DOI: 10.1111/php.12704.
  12. Mirza JD, Migotto ÁE, Yampolsky IV, de Moraes GV, Tsarkova AS, Oliveira AG. Chaetopterus variopedatus bioluminescence: A review of light emission within a species complex. Photochem Photobiol. 2020; 96 (4): 768–78. DOI: 10.1111/php.13221.
  13. Shimomura O, Johnson FH. Chaetopterus photoprotein: crystallization and cofactor requirements for bioluminescence. Science. 1968; 159 (3820): 1239–40. DOI: 10.1126/ science.159.3820.1239.
  14. Purtov KV, Petushkov VN, Rodionova NS, Pakhomova VG, Myasnyanko IN, Myshkina NM, et al. Luciferin-Luciferase system of marine polychaete Chaetopterus variopedatus. Dokl Biochem Biophys. 2019; 486 (1): 209–12. DOI: 10.1134/ S1607672919030104.