ORIGINAL RESEARCH
Antitumor effect of radiation therapy on orthotopic PDX models of human esophageal adenocarcinoma
National Medical Research Center of Oncology, Rostov-on-Don, Russia
Correspondence should be addressed: Alexandra A. Kiblitskaya
14 Liniya, 63, Rostov-on-Don, 344037; moc.liamg@dnaelabik
Author contribution: Kiblitskaya AA — data processing, manuscript preparation, technical editing, reference list, figures; Goncharova AS, Maslov AA — study concept and design, manuscript preparation; Anisimov AE — study concept and design, manuscript preparation, data acquisition, analysis and interpretation; Snezhko AV — content editing, manuscript preparation; Dimitriadi SN — data analysis and interpretation, technical editing; Gevorkyan YA — content editing; Kolesnikov EN — content and technical editing.
Ethical standards: the study fully complied with the principles of the Declaration of Helsinki; all requirements for animal housing were met; surgical interventions were conducted following the guidelines on the Care and Use of Laboratory Animals. The donors provided informed consent for their biological samples to be used in the study.
- Gladilina IA, Tryakin AA, Zahidova FO, Malihova OA, Ivanov SM, Kravec OA, i dr. Rak pishhevoda: jepidemiologija, faktory riska i metody diagnostiki. Onkologicheskij zhurnal: luchevaja diagnostika, luchevaja terapija. 2020; 3 (1): 69–76. Russian.
- Ho ALK, Smyth EC. A global perspective on esophageal cancer: two diseases in one. The Lancet Gastroenterology & Hepatology. 2020; 5 (6): 521–2. DOI: 10.1016/S2468-1253(20)30047-9.
- Enzinger PC, Mayer RJ. Esophageal cancer. New England Journal of Medicine. 2003; 349 (23): 2241–52.
- Lin EW, Karakasheva TA, Hicks PD, Bass AJ, Rustgi AK. The tumor microenvironment in esophageal cancer. Oncogene. 2016; 35 (41): 5337–49.
- Aksel EM. Statistika zlokachestvennyh novoobrazovanij zheludochno-kishechnogo trakta. Sibirskij onkologicheskij zhurnal. 2017; 16 (3): 5–11. DOI: 10.21294/1814-4861-2017-3-5-11. Russian.
- Kit OI. Nejrojendokrinnye, klinicheskie i morfologicheskie aspekty raka zheludka. Novocherkassk: Lik, 2014; 221 s. Russian.
- Ishihara R, Oyama T, Abe S, Takahashi H, Ono H, Fujisaki J et al. Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population. Journal of gastroenterology. 2017; 52 (7): 800–8. DOI: 10.1007/s00535016-1275-0.
- Mahoney JL, Condon R. E. Adenocarcinoma of the esophagus. Annals of surgery. 1987; 205 (5): 557.
- Urmonov UB, Dobrodeev AYu, Afanasev SG, Avgustinovich AV, Cheremisina OV. Sovremennye aspekty lechenija raka pishhevoda. Sibirskij onkologicheskij zhurnal. 2019; 18 (4): 78–84. DOI: 10.21294/1814-4861-2019-18-4-78-84. Russian.
- Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, et al. Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discov. 2014; 4: 998–1013. DOI: 10.1158/2159-8290.
- Wilding JL, Bodmer WF. Cancer Cell Lines for Drug Discovery and Development. Cancer Res. 2014; 74 (9): 2377–84. DOI: 10.1158/0008-5472.CAN-13-2971.
- Sung-Yup Cho. Patient-derived xenografts as compatible models for precision oncology. Laboratory Animal Research. 2020; 36: 14. DOI: 10.1186/s42826-020-00045-1.
- Zhuo J, Su R, Tan W, Lian Z, Lu D, Xu X. The ongoing trends of patient-derived xenograft models in oncology. Cancer Commun (Lond). 2020; 40 (11): 559–63. DOI: 10.1002/cac2.12096.
- Fernandes DP, Pimentel MML, Santos FAD, Praxedes ÉA, Brito PD, Lima MA, Lelis ICNG, Macedo MF, Bezerra MB. Hematological and biochemical profile of BALB/c nude and C57BL/6 SCID female mice after ovarian xenograft. An Acad Bras Cienc. 2018; 90 (4): 3941–48. DOI: 10.1590/0001-3765201820180586.
- Zhukova GV, Shihlyarova AI, Sagakyanc AB, Protasova TP. O rasshirenii variantov ispol'zovanija myshej BALB/c nude dlja jeksperimental'nogo izuchenija zlokachestvennyh opuholej cheloveka in vivo. Juzhno-Rossijskij onkologicheskij zhurnal. 2020; 1 (2): 28–35. Russian.
- Szadvari I, Krizanova O, Babula P. Athymic nude mice as an experimental model for cancer treatment. Physiol Res. 2016; 65 (Suppl 4): S441–53. DOI: 10.33549/physiolres.933526.
- Pompili L, Porru M, Caruso C, Biroccio A, Leonetti C. Patientderived xenografts: a relevant preclinical model for drug development. J Exp Clin Cancer Res. 2016; 35 (1): 189. DOI: 10.1186/s13046-016-0462-4.
- Choi YY, Lee JE, Kim H, Sim MH, Kim K.-K., Lee G, et al. Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer. Sci Rep. 2016; 6: 22172. DOI: 10.1038/srep22172.
- Hoffman RM. Patient-derived orthotopicxenografts: better mimic of metastasis than subcutaneous xenografts. Nat Rev Cancer. 2015; 15: 451–2. DOI: 10.1038/nrc3972.
- Tétreault MP. Esophageal cancer: insights from mouse models. Cancer growth and metastasis. 2015; 8: 37–46. DOI: 10.4137/ CGM.S21218.
- Bhargava S, Hotz B, Buhr HJ, Hotz HG. An orthotopic nude mouse model for preclinical research of gastric cardia cancer. Int J Colorectal Dis. 2009; 24: 31–9. DOI: 10.1007/s00384-0080584-z.
- Rostovcev NM, Kotljarov NA. Sravnitel'nyj analiz jeffektivnosti luchevogo i fotodinamicheskogo lechenija jeksperimental'noj opuholi. Pediatricheskij vestnik Juzhnogo Urala. 2015; 1: 29–32. Russian.
- Kolesnikov EN, Kit SO, Lukbanova EA, Goncharova AS, Maksimov AYu, avtory. Federal'noe gosudarstvennoe bjudzhetnoe uchrezhdenie "Rostovskij nauchno-issledovatel'skij onkologicheskij institut" Ministerstva zdravoohranenija Rossijskoj Federacii, patentoobladatel'. Sposob ortotopicheskoj transplantacii kul'tury opuholevyh kletok pishhevoda cheloveka v shejnyj otdel pishhevoda immunodeficitnyh myshej. Patent RF 2713798. G09B 23/28. Zajavka # 2019113616 ot 30.04.19. Russian.
- Spiegelberg L, van Hoof SJ, Biemans R, Lieuwes NG, Marcus D, Niemans R, et al. Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity. Radiother Oncol. 2019; 141: 247–55. DOI: 10.1016/j.radonc.2019.06.034.
- Shi J-J, Xing H, Wang Y-Х, Zhang X, Zhan Q-М, Geng M-Y, et al. PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment. Cancer Letters. 2019; 459: 145–55. DOI: 10.1016/j.canlet.2019.05.040.
- Teicher BA, Andrews PA, editors. Anticancer Drug Development Guide. Preclinical screening, clinical trials, and approval. 2nd ed. Totowa, New Jersey: Humana Press; 2004. DOI: 10.1007/978-159259-739-0.
- Treshhalina EM. Immunodeficitnye myshi Balb/c nude i modelirovanie razlichnyh variantov opuholevogo rosta dlja doklinicheskih issledovanij. RBZh. 2017; 16 (3): 6–13. DOI: 10.17650/1726- 9784-2017-16-3-6-13. Russian.