Hepatocellular adenoma is a rare benign liver tumor with the potentially unfavorable course due to the risk of hemorrhage and malignant transformation. Treatment depends on the mass subtype and size. Here we present a clinical case of hepatocellular adenoma in a woman of reproductive age developed against the background of the long-term use of oral contraceptives. The tumor sized 8 cm was detected accidentally during instrumental examination; morphological and immunohistochemistry assessment confirmed that it was a benign one without β-catenin mutation. Liver resection was performed. The case highlights the importance of careful monitoring of the patients during the long-term use of oral contraceptives, as well as of the timely surgical interventions in individuals with large hepatocellular adenomas to prevent hemorrhage and malignization.