The temperature dependence of the electrophoretic mobility of erythrocytes loaded with cryoglobulins, isolated from serum of patients with various diseases and different forms of a disease (systemic lupus erythematosus, chronic glomerulonephritis, atherothrombotic and cardioembolic ischemic stroke options) was investigated. Erythrocytes were obtained from healthy donors' blood. It was established that cryoglobulins significantly changed electrophoretic mobility of erythrocytes. This change may be in different directions: both upward and downward, depending on the nature of the disease and forms of its manifestation. It was shown that cryoglobulins complexes decompose at elevated temperatures. It was concluded that the electrophoretic method for estimating cryocomplexes is quite informative, in particular, to assess the extent of their heterogeneity.