Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

SCImago Journal & Country Rank

Log In Registration RU

Issue 4, 2020

TOPIC MICRORNA IN OCULAR PATHOLOGY

Contents Download
Issue 5, 2019

TOPIC IMMUNO-ONCOLOGY

A gradual understanding of the processes of tumor formation at the cellular and molecular level provides new tools to fight cancer. Today, methods of “attracting attention” of the immune system to tumor cells come to the fore. Immunooncology is a branch of medicine whose therapeutic focus is immunotherapy of tumors. In particular, adoptive immunotherapy using genetically modified autologous T-lymphocytes with an artificial receptor of a given specificity (CAR-therapy). A review of this issue is devoted to existing genetic engineering approaches to tumor immunotherapy.

Contents Download
Issue 6, 2019

TOPIC REHABILITATION

Two years ago we already had an issue, dedicated to rehabilitation. And this is the first repeat of the issue topic in four years of the journal release with our team. The repetition is justified by the extreme relevance of the topic of rehabilitation in modern medicine and modern society, when a person is not yet mature enough for a preventive approach to his health. A person is not ready to take care of himself, avoiding premature violations. In such conditions, rehabilitation remains one of the key elements of the healthcare system, returning a person to the society after unnecessary body breakdowns.

Contents Download
Issue 1, 2020

TOPIC PHYLOGENETIC ANALYSIS

Contents Download
Issue 2, 2020

TOPIC COVID-19

Contents Download
Issue 3, 2020

TOPIC CIRCULATING RNA

Contents Download

PUBLICATION FEES

New articles

Gaydina TA, Dvornikova EG

Early detection of melanocytic nevus progression to malignant melanoma is a pressing concern. Traditionally, patients with multiple melanocytic nevi (MMN) are monitored for extended periods of time and excisional biopsies are performed on individual suspicious melanocytic nevi (MN). This approach is costly and tremendously time-consuming for both doctors and patients. The aim of this study was to evaluate the efficacy of a smartphone-compatible optical instrument in the assessment of MN for malignancy. Seven patients aged 43 to 65 years with MMN on the trunk and upper/lower extremities were followed-up for 4 years. Dermoscopy images of MN were taken and analyzed using a Handyscope smartphone-compatible optical system operated at 20x magnification and a Handyscope3 application. A total of 74 MN were surgically removed during the follow-up period. None of the patients had melanoma. The results of dermoscopy image analysis generated by the convolutional neural network coincided with histopathology findings in all cases. The optical Handyscope system demonstrated its efficacy in assessing MN for malignancy. AI can be used for primary screening of MMN dermoscopy images. However, histopathological verification of the diagnosis is still needed.

Received: 2020-09-11

Published online: 2020-10-27

DOI: 10.24075/brsmu.2020.065

Comments 0

VIEWS 10

Voroshilina ES, Zornikov DL, Ivanov AV, Pochernikov DG, Panacheva EA

To this day semen microbiota is still poorly understood, and clinical significance of detecting specific microorganism groups has not been clearly determined. The aim of this work was to conduct cluster analysis of semen microbiota detected using real-time PCR. 634 semen samples of reproductive age men were analyzed using the Androflor kit. Microbial DNA in the quantity of no less than 103 GE/ml was detected in 460 samples (72.5%). From 1 to 14 microorganism groups were detected in 350 samples (55.2%) in the quantities that exceeded the threshold values (the detection rate of specific groups: 3.3–21.0%). In these 350 samples 4 stable microbiota clusters were determined. Each of the clusters was characterized by the prevalence of a specific microorganism group: obligate anaerobes (cluster 1; n = 172; detection rate — 49.1%), Lactobacillus spp. (cluster 2; n = 78; detection rate — 22.3%), gram-positive facultative anaerobes (cluster 3; n = 62; detection rate — 17.7%), Enterobacteriaceae / Enterococcoccus (cluster 4; n = 62; detection rate — 10.9%). Cluster 1 was less stable and was characterized by the larger species diversity compared to other clusters.

Received: 2020-09-21

Published online: 2020-10-27

DOI: 10.24075/brsmu.2020.064

Comments 0

VIEWS 9

Takhchidi KhP, Takhchidi NKh, Kasmynina TA, Tebina EP, Mokrunova MV

Eales’ disease is an idiopathic occlusive inflammatory vasculopathy resulting in peripheral retinal ischemia, neovascularization, recurrent hemophthalmos, and proliferative tissue formation. It is often complicated by tractional retinal detachment, secondary glaucoma, and central retinal vein occlusion. The management of patients with Eales’ disease includes mainly glucocorticosteroid therapy, the use of angiogenesis inhibitors, vitreoretinal surgery and laser photocoagulation. The clinical case reported demonstrates the potential of retinal laser photocoagulation for treatment of the Eales’ disease in the ischemic and proliferative stages. The results of retinal laser photocoagulation used as monotherapy demonstrate the clinical and functional indices improvement: enhanced visual acuity, stabilized central retinal sensitivity value, restored clarity to the ocular media, regression of neovascularization and macular edema in the patient’s eye being in the proliferative (3b) stage, and the process stabilization in the eye being in the ischemic (2a) stage of the disease.

Received: 2020-09-20

Published online: 2020-10-23

DOI: 10.24075/brsmu.2020.063

Comments 0

VIEWS 33

Tairova RT, Gaydina TA, Dvornikov AS, Tazartukova AD, Lyang OV

Patients with severe SARS-CoV-2 infection (COVID-19) and multiple comorbidities should be monitored for possible adverse reactions to prescribed drugs, including drug eruptions (DE) at any stage of treatment. Below, we describe a clinical case of a 92-year-old female patient with severe PCR-confirmed COVID-19. The patient was treated with amoxicillin/clavulanic acid, moxifloxacin, acetylcysteine, and sodium enoxaparin. On day 9 into treatment, the patient developed moderately itching macular rashes showing a tendency to coalesce, but overall showed no signs of deterioration. On day 15, the rashes regressed, following a short course of dexamethasone and chloropyramine. This kind of skin reaction might have been provoked by β-lactams and fluoroquinolones included in the treatment regimen, a secondary bacterial infection, compromised immunity due to advanced age, and high viral load associated with dermatological symptoms. Delayed onset of skin symptoms might be regarded as a marker of COVID-19 severity.

Received: 2020-09-23

Published online: 2020-10-21

DOI: 10.24075/brsmu.2020.062

Comments 0

VIEWS 76

Submit Manuscript

Popular articles

Sorokin MYu, Kasyanov ED, Rukavishnikov GV, Makarevich OV, Neznanov NG, Lutova NB, Mazo GE

The COVID-19 pandemic imposed not only serious threats to the physical health of the population, but also provoked a wide range of psychological problems. The study was aimed to define the structure of anxiety in the population during the epidemic period, as well as to identify the most vulnerable social groups (including individuals with affective disorders) which were most in need of psychological and/or psychiatric help. The online survey of 1957 Russian-speaking respondents aged over 18 was carried out from March 30 to April 5, 2020. The anxiety distress level was verified using the Psychological Stress Measure (PSM-25), the stigmatization of individuals experiencing respiratory symptoms was assessed using the modified Perceived Devaluation-Discrimination Questionnaire (PDD; Cronbach's α = 0.707). In 99.8% of respondents, the combination of various concerns associated with COVID-19 was observed, the mean psychological stress score was increased to moderate level (score 104.9 ± 34.4), and the stigmatization score exceeded the whole sample median value (19.5±3.4; Me = 17). About 35% of respondents had concerns associated with anxiety distress (Cohen’s d = 0.16–0.39): these were the "risk of social isolation" and the "possible lack of medication for daily use". The following groups of respondents were the most susceptible to the stress: people with affective disorders, young people (aged ≤20), unemployed persons, single persons, people with no formal education, and women. Thus, the broad sectors of the population need correction of anxiety distress associated with the COVID-19 pandemic. Therefore, the measures’ implementation should be targeted, and in terms of coverage and content oriented to the identified vulnerable social groups.

Received: 2020-05-06

Published online: 2020-06-02

DOI: 10.24075/brsmu.2020.030

Comments 0

VIEWS 804

Nersisyan SA, Shkurnikov MYu, Osipyants AI, Vechorko VI

Coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, enters the cell by binding the cell surface proteins: angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). The expression of these proteins varies significantly in individual organs and tissues of the human body. One of the proteins’ expression regulation mechanisms is based on the activity of the microRNA (miRNA) molecules, small non-coding RNAs, the most important function of which is the post-transcriptional negative regulation of gene expression. The study was aimed to investigate the mechanisms of the interactions between miRNA isoforms and ACE2/TMPRSS2 genes in the colon tissues known for the high level of expression of the described enzymes. The search for interactions was performed using the correlation analysis applied to the publicly available paired mRNA/miRNA sequencing data of colon tissues. Among the others, such miRNAs as miR-30c and miR-200c were identified known for their involvement in the coronavirus infection and acute respiratory distress syndrome pathogenesis. Thus, new potential mechanisms for the ACE2 and TMPRSS2 enzymes regulation were ascertained, as well as their possible functional activity in a cell infected with coronavirus.

Received: 2020-04-17

Published online: 2020-04-29

DOI: 10.24075/brsmu.2020.024

Comments 0

VIEWS 789

Special Project Author's Work

Secrets of a quality research study and a good manuscript

At the end of 2015, Bulletin of RSMU saw an important change in its typographic design and content. We formulated new editorial policies and established strict ethical standards for submitted manuscripts in accordance with the guidelines of reputable international bodies. As a result, about a quarter of the submitted works have been rejected, the primary reason being the author trying to submit a previously published article. Sometimes authors believe that by making slight changes to the introduction, excluding a few people from the study, performing a new statistical analysis, and thus obtaining totally new results they will turn their old manuscript into a novel work. That is why we would like to talk about scientific integrity, honesty, plagiarism, and self-plagiarism in our special project “Author’s work”.

American physicist Richard P. Feynman, a Nobel laureate, was always very scrupulous about the quality of a research study. During his commencement address at the California Institute of Technology in 1974, he talked about scientific integrity and honesty and warned young researchers “not to fool” themselves. A must-read for anyone who believes he/she is a true scientist.

In 1918, Russian physiologist Ivan Pavlov, a Nobel laureate, delivered two lectures: on the mind in general and the Russian mind in particular; on those mind qualities that determine the success of a research work and on how these qualities are present in the Russian mind. Pavlov's thoughts are an effective vaccine against poor intellectual work.

2019-03-31 Our news

Update regulations - Fast-Track

Thanks to APC, we have significantly enhanced the work of the editorial board and are finally able to introduce a normal (international) fast track! For articles submitted after 01 Apr 2019, the editors promise to maintain the following time limit: editorial rejection - 3 days after submission, decision - 2 weeks after submission, online publication - 4 weeks after submission.

2018-12-01 Our news

All articles now a fee-based

In connection with the decrease in University support of the journal, from 2019 the journal will charge for all published articles (except for editorial reviews). Since 2019, the size of the fee will be: if source of funding indicated in the article - USD 700, if not - USD 400. New fee will be charged for publications received after 01/12/2018.