Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Issue 4, 2026

Topic PRP for injuries

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Issue 5, 2025

Topic Age-related alterations in the immune system

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Issue 6, 2025

Topic Anxiety and depressive disorders

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Issue 1, 2026

Topic Miscarriage

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Issue 2, 2026

Topic Postmenopause

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Issue 3, 2026

Topic Meckel's diverticulum

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PUBLICATION FEES

New articles

Tkachenko VV, Vorobyeva PE, Mosnaya AI, Khachatryan KA, Chnavayan DV, Chikun SV, Zaynullina RF, Kirsanova PV, Moiseeva AD

Ureteral metastasis from prostate cancer is an exceedingly rare manifestation of disease progression and may mimic a primary tumor of the upper urinary tract. The limited number of reported cases underscores both the uniqueness of this localization and the substantial diagnostic challenges it presents. This report describes a clinical case of delayed metastatic ureteral lesion in a prostate cancer patient 13 years after radical prostatectomy. At primary diagnosis, the neoplasm in the ureter was regarded as urothelial carcinoma. Following surgical resection and immunohistochemical analysis, the tumor was confirmed to be a metastasis from prostate adenocarcinoma (PSA+, CK7–/CK20–). This case illustrates the diagnostic complexity of atypical prostate cancer progression and underscores the need for a comprehensive pathomorphological evaluation to confirm the diagnosis and guide subsequent treatment decisions.

Received: 2026-08-25

Published online: 2026-10-08

DOI: 10.24075/brsmu.2026.055

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VIEWS 44

Shabunin AV, Bagatelia ZA, Karpov AA, Maer RYu, Gugnin AV, Vengerov VYu, Pilyus FG, Karapetyan VD

Cholelithiasis is a common surgical disorder creating a high burden of the healthcare system. The introduction of minimally invasive technologies justifies the shift towards hospital-replacing models, but the institutional aspects of their use in the metropolis are still poorly understood. The study aimed to assess the role of hospital-replacing technologies in organizing elective surgical care provision to patients with cholelithiasis based on the retrospective analysis data for the years 2016–2025. A retrospective observational study was conducted based on the aggregate data of the Moscow City Health Department. The dynamics and structure of elective cholecystectomy procedures, the development of the short-stay unit (SSU) network, length of hospital stay, and age distribution were analyzed. The number of laparoscopic cholecystectomy procedures increased by 48%, the number of open surgical interventions decreased by 93.4%. The SSU network expanded from 5 to 30 units, the share of surgery due to cholelithiasis performed at the SSU reached 40.2% relative to the year 2016. The SSU stay was associated with the 75.0% bed-day reduction (to one day) and the actual hospital stay reduction by more than 80.0% (to 16.2 ± 7.4 h) compared to the round-the-clock hospital (RCH). Age differences (the share of patients over the age of 70 was 13.3% in the SSU vs. 36.0% in the RCH) support selective routing of patients at lower risk to the SSU. Conclusions: SSU has become an important organizational instrument of elective surgery due cholelithiasis that has ensured a sharp patient treatment time reduction over the preceding 10 years.

Received: 2026-08-24

Published online: 2026-09-29

DOI: 10.24075/brsmu.2026.054

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VIEWS 118

Enzel DA, Kriventsov MA

Pulmonary fibrosis is characterized by irreversible remodeling of the lung tissue, with limited treatment options. Selective vitamin D receptor (VDR) agonists are regarded as promising antifibrotic agents, but the dose dependence of their effects in pulmonary fibrosis has been little studied. The aim of the experimental study was to carry out a comparative analysis of the effects of two doses of paricalcitol in experimental aerosol bleomycin-induced pulmonary fibrosis. The experiment was performed on 60 Wistar rats: an intact group (n = 6), a control group with fibrosis modeling (n = 18), and two experimental subgroups with intraperitoneal administration of paricalcitol at doses of 0.1 μg/animal (EG-A; n = 18) and 0.5 μg/animal (EG-B; n = 18) once every 3 days. The animals were withdrawn from the experiment on days 10, 20, and 30, with histopathological analysis and scoring on the modified Ashcroft scale, immunohistochemical study (CD68, CD80, CD163, MMP-9, TGF-β1, p38 MAPK, VDR), and analysis of the relative mRNA expression of IL1β, TNFα, TGF-β1, and SMA-α. Both doses of paricalcitol reduced the severity of the inflammatory and fibrotic changes, but the effect was dose-dependent: on day 30 the Ashcroft score was 5.01 ± 0.45 points in the control, 3.40 ± 0.28 in EG-A (–32.1%), and 2.12 ± 0.25 in EG-B (–57.7%; p < 0.05 compared with EG-A). Paricalcitol limited the early M1 response, reduced the number of CD163+ macrophages, and suppressed the expression of TGF-β1, MMP-9, and p38 MAPK. With the high dose, by day 30 the mRNA levels of IL1β, TNFα, TGF-β1, and SMA-α did not differ from those in the intact group. Thus, the antifibrotic action of paricalcitol is dose-dependent and is most pronounced at the later stages of the experiment.

Received: 2026-08-22

Published online: 2026-09-28

DOI: 10.24075/brsmu.2026.053

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VIEWS 147

Asmaeva PV, Borisova OYu, Pimenova AS, Andrievskaya IYu, Chaplin AV, Kafarskaya LI, Efimov BA, Evseev PV

Bordetella bronchiseptica is a respiratory pathogen of humans and animals that infects a wide range of hosts. This study aimed to characterize the phylogenetic position and genomic features of 31 laboratory isolates of B. bronchiseptica, 25 of which were obtained from humans and six from animals. The studied isolates were compared with 30 reference genomes of B. bronchiseptica, B. pertussis, and B. parapertussis. The analysis included the determination of average nucleotide identity (ANI), phylogenetic reconstruction based on 120 marker proteins and 42 ribosomal proteins, and the identification of virulence factors, potential antibiotic resistance genes, prophage regions, and antiphage defense systems. A subsample of 20 genomes has also been subjected to pangenomic and metabolic analyses. In the overall dataset, B. pertussis and B. parapertussis formed compact clades, whereas B. bronchiseptica isolates were distributed across several phylogenetic lineages. B. bronchiseptica lines differed in their repertoires of virulence factors, putative antibiotic-resistance determinants, prophages, and antiphage defense systems. In the subsample of 20 genomes, representatives of the classical Bordetella retained the main modules of central metabolism and a substantial proportion of the shared gene clusters. The resulting data demonstrate a pronounced phylogenetic and functional genomic heterogeneity of B. bronchiseptica.

Received: 2026-08-12

Published online: 2026-09-27

DOI: 10.24075/brsmu.2026.052

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VIEWS 194

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Popular articles

Zinoveva AA, Bakhchinian E, Kamenkov SS, Shcherbakova LN, Bugerenko AE, Ogay DS, Voloshin NS, Chechekhina ES, Kulebyakin KYu

The menopausal transition is accompanied by the decrease in estrogen levels and changes in the estrogen to androgen ratio, resulting in dysregulation of multipotent mesenchymal stem cell (MSCs) differentiation in the subcutaneous adipose tissue, reduction of their adipogenic potential, adipocyte hypertrophy, and metabolic disorder progression. Menopausal hormone therapy (MHT) is used to manage menopausal symptoms. However, the effects of exogenous hormones on MSCs are still poorly understood. The study aimed to assess adipogenic differentiation of the subcutaneous adipose tissue MSCs and their sensitivity to testosterone, 17β-estradiol, and parathyroid hormone (PTH) in postmenopause. A total of six patients with benign gynecological disorders were included in the study, among them two were of reproductive age, one was perimenopausal, and three were postmenopausal. The MSCs adipogenic differentiation was performed throughout 14 days with the addition of testosterone, 17β-estradiol, or PTH, 10 nM each, then the proportion of cells containing lipid droplets was assessed. The adipogenesis level in control samples was 26–30% in patients of childbearing age and 12–42% in postmenopausal ones, with the pronounced interindividual variability. Hormonal stimulation considerably suppressed MSCs adipogenesis in postmenopause: testosterone reduced adipogenesis to 46–56% of control levels, estradiol to 51–84%, PTH to 53–66%, while patients of childbearing age showed a less pronounced effect (65–85%). The obtained data demonstrate a shift in hormonal sensitivity of MSCs from subcutaneous adipose tissue in postmenopause and suggest that MHT may exert an additional inhibiting effect on adipogenesis through suppression of MSCs differentiation.

Received: 2026-03-09

Published online: 2026-04-16

DOI: 10.24075/brsmu.2026.013

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VIEWS 982

Saadoon SJ, Atiyah AM, Ibrahim AH, Mostafa FM

Secondary hyperparathyroidism (SHPT) is a common and progressive complication of chronic kidney disease (CKD), often intensifying as patients reach dialysis. Although alfacalcidol and other active vitamin D analogs are often used, improper administration can raise the risk of hypercalcemia and hyperphosphatemia. This study aimed to assess, using clinical criteria indicated by guidelines, whether alfacalcidol should be prescribed to hemodialysis patients with SHPT. Records of 136 adult patients treated in An-Naseria hemodialysis units were reviewed and analyzed using SPSS (version 26). The appropriateness of prescribing alfacalcidol was evaluated in accordance with KDIGO 2017 guidelines, taking into account levels of phosphate, calcium, and parathyroid hormone (PTH). Patients were divided into groups based on whether their prescriptions were appropriate or possibly inappropriate. Patients were 55.1% male and had an average age of 51.42 ± 11.5years. The majority of patients exhibited biochemical values (phosphate: 79.4%, calcium: 74.3%, and PTH: 77.2% normal) within goal ranges. 72 patients (52.9%) were categorized as potentially inappropriate for alfacalcidol medication, whereas 64 patients (47%) were recognized as having appropriate indications based on criteria consistent with guidelines. The mean PTH levels of patients in the appropriate group were substantially higher (923.14 ± 379.59 pg/mL) than those in the inappropriate group (274.71 ± 179.69 pg/mL, р < 0.001). Age, sex, calcium, and phosphate levels did not significantly correlate with prescription appropriateness. This cohort may have a significant percentage of alfacalcidol prescriptions that may not follow current guidelines. The sensible use of vitamin D analogs in hemodialysis patients may be improved by better adherence to evidence-based guidelines and routine biochemical monitoring.

Received: 2026-04-13

Published online: 2026-05-30

DOI: 10.24075/brsmu.2026.025

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VIEWS 940

Special Project Author's Work

Secrets of a quality research study and a good manuscript

At the end of 2015, Bulletin of RSMU saw an important change in its typographic design and content. We formulated new editorial policies and established strict ethical standards for submitted manuscripts in accordance with the guidelines of reputable international bodies. As a result, about a quarter of the submitted works have been rejected, the primary reason being the author trying to submit a previously published article. Sometimes authors believe that by making slight changes to the introduction, excluding a few people from the study, performing a new statistical analysis, and thus obtaining totally new results they will turn their old manuscript into a novel work. That is why we would like to talk about scientific integrity, honesty, plagiarism, and self-plagiarism in our special project “Author’s work”.

American physicist Richard P. Feynman, a Nobel laureate, was always very scrupulous about the quality of a research study. During his commencement address at the California Institute of Technology in 1974, he talked about scientific integrity and honesty and warned young researchers “not to fool” themselves. A must-read for anyone who believes he/she is a true scientist.

In 1918, Russian physiologist Ivan Pavlov, a Nobel laureate, delivered two lectures: on the mind in general and the Russian mind in particular; on those mind qualities that determine the success of a research work and on how these qualities are present in the Russian mind. Pavlov's thoughts are an effective vaccine against poor intellectual work.