The aim of this study was to evaluate the efficacy of using intravenous form of proton pump inhibitors in treatment of patients with upper gastrointestinal bleeding. The study included 71 patients. 30 patients in the first group received parenteral antisecretory therapy with omeprazole and the second group of 41 patients received omeprazole in capsules. The study confirmed the effectiveness of medicamental hemostasis with the usage of intravenous proton pump inhibitors in patients of that group as a part of a combined therapy based on the method of endoscopic prevention of recurrent hemorrhage.