I Survey of literature shows the current understanding of the etiology, pathogenesis, clinical presentation of an age-related frailty syndrome, as well as methods of its correction. There are analyzed the characteristics of the diagnosis of sarcopenia and its role in the occurrence of main symptoms of senile frailty. It is underlined the leading role of age-related changes in nervous- endocrine system and increased sensibility to oxidative stress for the emergence and development of age-related frailty