ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Immediate and Long-Term Outcomes of Coronary Heart Disease, Depending on the Molecular Genetic Characteristics of Patients
About authors
1 Department of Propaedeutics of Internal Diseases and Radiodiagnostics, Pediatric Faculty,
Pirogov Pirogov Russian National Research Medical University, Moscow, Russia
2 Scientific Clinical Center of Gerontology,
Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Ilya Melentyev
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.liam@77vebylog
Received: 2014-05-26
Accepted: 2014-09-17
Published online: 2017-01-05
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Depending on the insertion-deletion polymorphism of the angiotensin-converting enzyme and Hindlll DNA polymorphism of lipoprotein lipase gene there were studied the clinical course of coronary heart disease and five-year survival of patients after an exacerbation of the disease. It was found that the most important genetic predictors of short- and long-term adverse outcomes of acute ischemic heart disease are the genotype H+H+ of lipoprotein lipase gene, DD genotype of the angiotensin-converting enzyme gene and the combination of these genotypes.
Keywords: polymorphism of the lipoprotein lipase gene, polymorphism of angiotensin converting enzyme gene, coronary heart disease, unstable angina pectoris, myocardial infarction