ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Spermatogenesis Status after Experimental Obstruction of the Seminal Tract in White Rats
About authors
1 Department of Urology, Medical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Department of Experimental Surgery,
Pirogov Pirogov Russian National Research Medical University, Moscow, Russia
3 Kulakov Federal Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Correspondence should be addressed: Olga Krasova
ul. 1-ya Leonova, d. 16, Moscow, Russia, 129226; ur.xednay@dedahs-revlis
Received: 2015-02-04
Accepted: 2015-04-22
Published online: 2017-01-05
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The aim of the study was to estimate the effect of the level and duration of the obstruction of the seminal tract on the morphological and functional state of the testicular tissue. 50 adult outbreed male laboratory rats were observed in the study. The rats were divided into 4 groups: 1 — vas deferens obstruction proximally, 2 — vas deferens obstruction distally, 3 — epididymis obstruction, 4 — controls (intact animals). The testes and epididymis were removed in 3 and 6 months for histological examination. Testicular volume and spermatogenesis status decreased in all groups. Also, these changes depend on the level and duration of the obstruction of the seminal tract.
Keywords: obstructive azoospermia, spermatogenesis, testicular morphology, obstruction of the seminal tract In rats