ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Surface phenotype of blood lymphocytes in children with medium axial myopia in the presence or absence of secondary immunodeficiency
About authors
1 Department of Anesthesiology, Resustication and Intensive Therapy, Medical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Department of Faculty Surgery No. 1, Medical Faculty,
A. I. Evdokimov Moscow State Medical and Dental University, Moscow
3 Diagnostic and Consultative Unit,Children’s Medical Centre of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia
Correspondence should be addressed: Nadezhda Khamnagdaeva
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.liam@hsa_assyl
Received: 2015-11-03
Accepted: 2016-01-20
Published online: 2017-01-05
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Investigating the role of secondary immunodeficiency in the development of myopia in children is a promising research area. We studied the surface phenotype of blood lymphocytes in healthy children and children with medium axial myopia in the presence or absence of secondary immunodeficiency clinical manifestations. The mean age of study participants was 16 ± 0.25 years. The control group and each of the two experimental subgroups included 8 children. Using indirect immunofluorescence, the expression of CD3, CD4, CD8, CD16, CD56, CD20, CD72, CD38, CD25, CD71, HLA-DR, CD95, CD54, mIgM, mIgG, ICAM-1 antigens was studied. For children with myopia and secondary immunodeficiency, only one statistically significant (p < 0.05) difference from the control group was detected, namely, a reduced expression of CD4 antigen. For children with myopia and without secondary immunodeficiency, a statistically significant (p < 0.05) increase in CD20 antigen expression and a reduced ICAM-1 antigen expression were observed.
Keywords: nearsightedness, myopia, medium axial myopia, secondary immunodeficiency, lymphocytes, lymphocyte surface phenotype, antigens