Increasing HIV prevalence among women and growing numbers of HIV-positive patients who choose to become pregnant prompt a discussion of management strategies applied to such patients. In this work we analyze a case of a pregnant HIV-positive woman with marked immunodeficiency who started seeking medical advice only after she had developed severe life-threatening secondary conditions. We look at the progression of comorbidities that led to the death of the patient and her baby and evaluate the chosen treatment plan. We also propose recommendations for the management of patients with similar pathologies that include psychological care, vigilance against possible atypical progression of a comorbidity, such as tuberculosis, and extensive diagnostic evaluation.