Статья размещена в открытом доступе и распространяется на условиях лицензии Creative Commons Attribution (CC BY).
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ
Нейрофизиологические маркеры иллюзии, вызванной зеркальной визуальной обратной связью
1 Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, Москва, Россия
2 Российский центр неврологии и нейронаук, Москва, Россия
3 Институт высшей нервной деятельности и нейрофизиологии, Москва, Россия
Для корреспонденции: Олеся Александровна Мокиенко
ул. Островитянова, д. 1, с. 1, г. Москва, 117997, Россия; ur.anhi@okneikom.o
Финансирование: работа выполнена в рамках Государственного задания Министерства здравоохранения Российской Федерации № 125022602910-2.
Благодарности: авторы признательны участникам исследования за их вклад в развитие научного знания.
Вклад авторов: О. А. Мокиенко — дизайн исследования, анализ результатов, написание статьи; П. Д. Бобров — анализ данных, написание статьи; А. А. Соловьева — проведение экспериментов, анализ результатов; М. Р. Исаев, Я. В. Керечанин — анализ данных; В. Ю. Ратникова, В. А. Катайцев — проведение экспериментов; Е. Д. Шагина — дизайн исследования, обсуждение результатов; В. Б. Никишина — концептуализация исследования, обсуждение результатов.
Соблюдение этических стандартов: исследование одобрено этическим комитетом Института клинической психологии и социальной работы РНИМУ им. Н. И. Пирогова (протокол № 28 от 23 октября 2024 г.). Все участники подписали добровольное согласие на участие в исследовании.
- Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996; 263: 377–86.
- Deconinck FJA, Smorenburg ARP, Benham A, Ledebt A, Feltham MG, Savelsbergh GJP. Reflections on Mirror Therapy: A Systematic Review of the Effect of Mirror Visual Feedback on the Brain. Neurorehabilitation and Neural Repair. 2015; 29: 349–61.
- Zhang JJQ, Fong KNK, Welage N, Liu KPY. The Activation of the Mirror Neuron System during Action Observation and Action Execution with Mirror Visual Feedback in Stroke: A Systematic Review. Neural Plast. 2018; 2018: 2321045.
- Zhang K, Ding L, Wang X, et al. Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial. Eur J Phys Rehabil Med. 2025; 61: 184–94.
- Zhuang J, Lei X, Guo X, Ding L, Jia J. Motor and parietal cortex activity responses to mirror visual feedback in patients with subacute stroke: An EEG study. Clin Neurophysiol Pract. 2025; 10: 12–21.
- Xie H-M, Zhang K-X, Wang S, et al. Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2022; 103: 988–97.
- Мокиенко О. А., Ивкина М. В. Методы лечения фантомной боли с позиций доказательной медицины. Российский неврологический журнал. 2023; 28(6): 11–18.
- Thieme H, Morkisch N, Mehrholz J, et al. Mirror therapy for improving motor function after stroke. Cochrane Database Syst Rev. 2018; 7: CD008449.
- Jaafar N, Che Daud AZ, Ahmad Roslan NF, Mansor W. Mirror Therapy Rehabilitation in Stroke: A Scoping Review of Upper Limb Recovery and Brain Activities. Rehabil Res Pract. 2021; 2021: 9487319.
- Kim H, Lee E, Jung J, Lee S. Utilization of Mirror Visual Feedback for Upper Limb Function in Poststroke Patients: A Systematic Review and Meta-Analysis. Vision (Basel). 2023; 7.
- McCabe CS, Haigh RC, Ring EFJ, Halligan PW, Wall PD, Blake DR. A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). Rheumatology (Oxford). 2003; 42: 97–101.
- Vladimir Tichelaar YIG, Geertzen JHB, Keizer D, Paul van Wilgen C. Mirror box therapy added to cognitive behavioural therapy in three chronic complex regional pain syndrome type I patients: a pilot study. Int J Rehabil Res. 2007; 30: 181–8.
- Pervane Vural S, Nakipoglu Yuzer GF, Sezgin Ozcan D, Demir Ozbudak S, Ozgirgin N. Effects of Mirror Therapy in Stroke Patients With Complex Regional Pain Syndrome Type 1: A Randomized Controlled Study. Arch Phys Med Rehabil. 2016; 97: 575–81.
- Machač S, Chasáková L, Kakawand S, et al. Mirror visual feedback as therapeutic modality in unilateral upper extremity complex regional pain syndrome type I: randomized controlled trial. Eur J Phys Rehabil Med. 2024; 60: 280–91.
- Bullock K, Won AS, Bailenson J, Friedman R. Virtual RealityDelivered Mirror Visual Feedback and Exposure Therapy for FND: A Midpoint Report of a Randomized Controlled Feasibility Study. J Neuropsychiatry Clin Neurosci. 2020; 32: 90–4.
- Limakatso K, Cashin AG, Williams S, Devonshire J, Parker R, McAuley JH. The Efficacy of Graded Motor Imagery and Its Components on Phantom Limb Pain and Disability: A Systematic Review and Meta-Analysis. Can J Pain. 2023; 7: 2188899.
- Rizzo M, Petrini L, Del Percio C, Lopez S, Arendt-Nielsen L, Babiloni C. Mirror visual feedback during unilateral finger movements is related to the desynchronization of cortical electroencephalographic somatomotor alpha rhythms. Psychophysiology. 2022; 59: e14116.
- Rizzo M, Del Percio C, Petrini L, Lopez S, Arendt-Nielsen L, Babiloni C. Cortical sources of electroencephalographic alpha rhythms related to the anticipation and experience of mirror visual feedback-induced illusion of finger movements. Psychophysiology. 2023; 60: e14281.
- Norris TA, Augenstein TE, Rodriguez KM, Claflin ES, Krishnan C. Shaping corticospinal pathways in virtual reality: effects of task complexity and sensory feedback during mirror therapy in neurologically intact individuals. J Neuroeng Rehabil. 2024; 21: 154.
- Yarossi M, Manuweera T, Adamovich SV, Tunik E. The Effects of Mirror Feedback during Target Directed Movements on Ipsilateral Corticospinal Excitability. Front Hum Neurosci. 2017; 11: 242.
- Tai R-Y, Zhu J-D, Chen C-C, Hsieh Y-W, Cheng C-H. Modulation of Functional Connectivity in Response to Mirror Visual Feedback in Stroke Survivors: An MEG Study. Brain Sci. 2021; 11.
- Cheng C-H, Lin S-H, Wu C-Y, Liao Y-H, Chang K-C, Hsieh Y-W. Mirror Illusion Modulates M1 Activities and Functional Connectivity Patterns of Perceptual-Attention Circuits During Bimanual Movements: A Magnetoencephalography Study. Front Neurosci. 2019; 13: 1363.
- Wang J, Fritzsch C, Bernarding J, et al. Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects. NeuroRehabilitation. 2013; 33: 593–603.
- Bai Z, Fong KNK, Zhang J, Hu Z. Cortical mapping of mirror visual feedback training for unilateral upper extremity: A functional near-infrared spectroscopy study. Brain Behav. 2020; 10: e01489.
- Tsou M-H, Chen P-Y, Hung Y-T, Lim Y-W, Huang S-L, Liu Y-C. Comparison of Brain Activation Between Different Modes of Motor Acquisition: A Functional Near-Infrared Study. Brain Behav. 2025; 15: e70238.
- Delorme A, Palmer J, Onton J, Oostenveld R, Makeig S. Independent EEG sources are dipolar. PLoS One. 2012; 7: e30135.
- Frolov A, Bobrov P, Biryukova E, et al. Using Multiple Decomposition Methods and Cluster Analysis to Find and Categorize Typical Patterns of EEG Activity in Motor Imagery Brain-Computer Interface Experiments. Front Robot AI. 2020; 7: 88.
- Dubová D, Dvořáčková D, Pavlů D, Pánek D. Cerebral Projection of Mirrored Touch via sLORETA Imaging. Life (Basel). 2023; 13. DOI:10.3390/life13051201.
- Seiyama A, Seki J, Tanabe HC, et al. Circulatory basis of fMRI signals: relationship between changes in the hemodynamic parameters and BOLD signal intensity. Neuroimage. 2004; 21: 1204–14.
- Seiyama A, Miura T, Okahashi S, Konishi N, Cassim M. Visual effects on tactile stimulation and its perception: A pilot study using near-infrared spectroscopy. MethodsX. 2024; 13: 102849.