Today, selection of the optimal treatment method in patients with the early-stage primary open-angle glaucoma (POAG) remains an urgent problem of ophthalmology. There are various approaches to treating such patients, including the use of topical therapy and laser treatments. The study aimed to assess the hypotensive effect and clinical and functional outcomes of the simultaneous combined laser treatment, including YAG-LAT and the subsequent one-time SLT in the same localization zones, in patients with the newly diagnosed early-stage POAG and moderately elevated intraocular pressure (IOP). The study included 100 eyes with stage I POAG, which were divided into two groups: group I — 50 eyes before and after YAG-LAT and SLT; group II – 50 eyes that underwent SLT only. The follow-up period was 12 months. In patients of groups I and II, a decrease in IOP by 28 and 30.5% relative to the baseline IOP was reported at 1 month, and by 32.2 and 32% at 3 months, respectively. The intergroup difference in the extent of IOP decrease at 1 and 3 months was non-significant (р > 0.05). There was still good hypotensive effect, up to 29.3% of the preoperative value, 12 months after YAG-LAT and SLT. Twelve months after SLT, the hypotensive effect was 17%. The intergroup difference in the extent of IOP decrease at 12 months was significant (р < 0.05). Glaucoma stabilization was reported in groups I and II, but in group II, antihypertensive therapy was required in 63% of cases. The simultaneous combined laser treatment technology (YAG-LAT and SLT) showed a pronounced, persistent hypotensive effect and glaucoma stabilization when used for treatment of the newly diagnosed early-stage POAG.