ISSN Print 2500–1094    ISSN Online 2542–1204
Bulletin of RSMU


Head of the Department of Innate Immunity and Immune Tolerance of the Institute of Immunology and Transfusion Medicine, Mannheim Medical Faculty,
Heidelberg University (Heidelberg, Germany)

Head of the Department of Translational Cellular and Molecular Biomedicine,
National Research Tomsk State University (Tomsk, Russia)

DSc (biology), professor

Areas of expertise:

translational cellular and molecular immunology, the role of innate immunity in the development of cardiovascular diseases and cancer, molecular mechanisms of chronic inflammation, activation and epigenetic programming of macrophages, cellular therapy and immunotherapy, regenerative immunology


Significant publications in last 5 years

  1. Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C, Schönhaber H, Weiss C, Fields AP, Simon-Keller K, Pfister F, Berlit S, Marx A, Arnold B, Goerdt S, Kzhyshkowska JStabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model. Oncotarget. 2016 May 24; 7 (21): 31097–110. DOI: 10.18632/oncotarget.8857.
  2. Alidori S, Bowman RL, Yarilin D, Romin Y, Barlas A, Mulvey JJ, Fujisawa S, Xu K, Ruggiero A, Riabov V, Thorek DL, Ulmert HD, Brea EJ, Behling K, Kzhyshkowska J, et al. Deconvoluting hepatic processing of carbon nanotubes. Nat Commun. 2016 Jul 29; 7: 12343. DOI: 10.1038/ncomms12343.
  3. Kzhyshkowska J, Yin S, Liu T, Riabov V, Mitrofanova I. Role of chitinase-like proteins in cancer. Biol Chem. 2016 Mar; 397 (3) :231–47. DOI: 10.1515/hsz-2015-0269.
  4. Özçelik H, Vrana NE, Gudima A, Riabov V, Gratchev A, Haikel Y, Metz-Boutigue MH, Carradò A, Faerber J, Roland T, Klüter H, Kzhyshkowska J, et al. Harnessing the multifunctionality in nature: a bioactive agent release system with self-antimicrobial and immunomodulatory properties. Adv Healthc Mater. 2015 Sep 16; 4 (13): 2026–36. DOI: 10.1002/adhm.201500546..
  5. Kzhyshkowska J, Gudima A, Riabov V, Dollinger C, Lavalle P, Vrana NE. Macrophage responses to implants: prospects for personalized medicine. J Leukoc Biol. 2015 Dec; 98 (6): 953–62. DOI: 10.1189/jlb.5VMR0415-166R. Review.
  6. Stankevich KS, Gudima A, Filimonov VD, Klüter H, Mamontova EM, Tverdokhlebov SI, Kzhyshkowska JSurface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: perspective for personalized therapy. Mater Sci Eng C Mater Biol Appl. 2015 Jun; 51: 117–26. DOI: 10.1016/j.msec.2015.02.047.
  7. Riabov V, Gudima A, Wang N, Mickley A, Orekhov A, Kzhyshkowska JRole of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis. Front Physiol. 2014 Mar 5; 5: 75. DOI: 10.3389/fphys.2014.00075.
  8. Kzhyshkowska J, Neyen C, Gordon S. Role of macrophage scavenger receptors in atherosclerosis. Immunobiology. 2012 May; 217 (5): 492–502. DOI: 10.1016/j.imbio.2012.02.015.
  9. Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, et al. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell. 2012 Feb 24; 45 (4): 505–16. DOI: 10.1016/j.molcel.2011.12.035.
  10. Schledzewski K, Géraud C, Arnold B, Wang S, Gröne HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schönhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011 Feb; 121 (2): 703–14. DOI: 10.1172/JCI44740.