Julia G KZYSHKOWSKA
Head of the Department of Innate Immunity and Immune Tolerance of the Institute of Immunology and Transfusion Medicine, Mannheim Medical Faculty,
Heidelberg University (Heidelberg, Germany)
Head of the Department of Translational Cellular and Molecular Biomedicine,
National Research Tomsk State University (Tomsk, Russia)
DSc (biology), professor
Areas of expertise:
translational cellular and molecular immunology, the role of innate immunity in the development of cardiovascular diseases and cancer, molecular mechanisms of chronic inflammation, activation and epigenetic programming of macrophages, cellular therapy and immunotherapy, regenerative immunology
My career choice was largely determined by a desire to understand what cellular and molecular processes lead to cancer, develop new approaches to early detection of cancer and find effective treatment for patients in the late stages of the disease. I was very much influenced by the traditions of Russian oncovirology and a viral theory of cancer origin suggested by Lev Zilber. The education I got at the Department of Virology of the Faculty of Biology (MSU) was unique in terms of the extensive encyclopedic knowledge it provided and the level of knowledge systematization. When I was working on my thesis and candidate degree dissertation at the Institute of Cancerogenesis of Blokhin Russian Cancer Research Center, I grew determined to devote my life to biomedical research. I think that the most promising direction of modern biomedicine is programming of the immune system to fight cancer, cardio-vascular and neurodegenerative diseases. I put a lot of effort into promoting scientific knowledge internationally, establishing international ties between scientists from different countries, and arranging international interdisciplinary projects and conferences. In modern Russia a gradual evolution of a research funding system, which is based on grant competitions, creates a favorable environment for young scientists and allows them to make advancements in those areas of research that seem to be the most promising and to make a successful career. Experience that young scientists gain in foreign and Russian research centers is a very important step to improving their qualifications and expanding their scientific horizons.
- Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C, Schönhaber H, Weiss C, Fields AP, Simon-Keller K, Pfister F, Berlit S, Marx A, Arnold B, Goerdt S, Kzhyshkowska J. Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model. Oncotarget. 2016 May 24; 7 (21): 31097–110. DOI: 10.18632/oncotarget.8857.
- Alidori S, Bowman RL, Yarilin D, Romin Y, Barlas A, Mulvey JJ, Fujisawa S, Xu K, Ruggiero A, Riabov V, Thorek DL, Ulmert HD, Brea EJ, Behling K, Kzhyshkowska J, et al. Deconvoluting hepatic processing of carbon nanotubes. Nat Commun. 2016 Jul 29; 7: 12343. DOI: 10.1038/ncomms12343.
- Kzhyshkowska J, Yin S, Liu T, Riabov V, Mitrofanova I. Role of chitinase-like proteins in cancer. Biol Chem. 2016 Mar; 397 (3) :231–47. DOI: 10.1515/hsz-2015-0269.
- Özçelik H, Vrana NE, Gudima A, Riabov V, Gratchev A, Haikel Y, Metz-Boutigue MH, Carradò A, Faerber J, Roland T, Klüter H, Kzhyshkowska J, et al. Harnessing the multifunctionality in nature: a bioactive agent release system with self-antimicrobial and immunomodulatory properties. Adv Healthc Mater. 2015 Sep 16; 4 (13): 2026–36. DOI: 10.1002/adhm.201500546..
- Kzhyshkowska J, Gudima A, Riabov V, Dollinger C, Lavalle P, Vrana NE. Macrophage responses to implants: prospects for personalized medicine. J Leukoc Biol. 2015 Dec; 98 (6): 953–62. DOI: 10.1189/jlb.5VMR0415-166R. Review.
- Stankevich KS, Gudima A, Filimonov VD, Klüter H, Mamontova EM, Tverdokhlebov SI, Kzhyshkowska J. Surface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: perspective for personalized therapy. Mater Sci Eng C Mater Biol Appl. 2015 Jun; 51: 117–26. DOI: 10.1016/j.msec.2015.02.047.
- Riabov V, Gudima A, Wang N, Mickley A, Orekhov A, Kzhyshkowska J. Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis. Front Physiol. 2014 Mar 5; 5: 75. DOI: 10.3389/fphys.2014.00075.
- Kzhyshkowska J, Neyen C, Gordon S. Role of macrophage scavenger receptors in atherosclerosis. Immunobiology. 2012 May; 217 (5): 492–502. DOI: 10.1016/j.imbio.2012.02.015.
- Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, et al. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell. 2012 Feb 24; 45 (4): 505–16. DOI: 10.1016/j.molcel.2011.12.035.
- Schledzewski K, Géraud C, Arnold B, Wang S, Gröne HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schönhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011 Feb; 121 (2): 703–14. DOI: 10.1172/JCI44740.