ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
METHOD
Assessment of the effectiveness of drug administration by infrasound phonophoresis and through the irrigation system in the retrobulbar space
About authors
1 Department of Faculty Surgery No. 1, Medical Faculty,
A. I. Evdokimov Moscow State Medical and Dental University, Moscow
2 Department of Radionuclide Diagnostics No. 44,
Municipal Clinical Hospital No. 1 named after N. l. Pirogov, Moscow, Russia
Correspondence should be addressed: Abib Aminulla
4-y Dobryninskiy pereulok, d. 1/9, Moscow, Russia, 119049; e-mail is not indicated
Received: 2011-12-12
Accepted: 2012-09-19
Published online: 2017-01-05
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The aim of this study was to compare the level of accumulation of the radiopharmaceutical (RPH) within the eye after an anterior noninjection method of infusing the drug into the conjunctival cavity followed by an insonation of the eye with infrasound (infrasound phonophoresis) and after injecting it through irrigation system in the retrobulbar space. The work was done on 10 Chinchilla rabbits. The animals were divided into testing and comparison groups, 5 rabbits in each. In the testing group the radiopharmaceutical was infused by an infrasound phonophoresis method. In the comparison group the radiopharmaceutical was injected into retrobulbar space through irrigation system. The conducted research showed that with the infusion of medical preparations by the infrasound phonophoresis method the level of accumulation of the radiopharmaceutical inside the eye was 1.9 times higher than the content of the radiopharmaceutical introduced in the retrobulbar space through irrigation system.
Keywords: radiopharmaceutical, infrasound, phonophoresis, application