Evaluation of the effectiveness of metabolic therapyof acute peritonitis

Vlasov AP1, Shibitov VA2, Vasilyev VV1, Anaskin SG1, Vlasov PA1, Potyanova IV1
About authors

1 Department of Faculty Surgery, Medical Institute,
Mordovia State University named after N. P. Ogarev, Saransk, Russia

2 Laboratory of Bioactive Compounds, Research Institute of Pharmacy,
I. M. Sechenov First Moscow State Medical Unversity, Moscow, Russia

Correspondence should be addressed: Aleksey Vlasov
ul. Bolshevistskaia, d. 68, Saransk, Rissia, 430005; ur.xednay@16.pav

Received: 2012-06-01 Accepted: 2012-09-19 Published online: 2017-01-05

The research of laboratory and clinical effects of a new antihypoxant at an acute peritonitis with an accent on studying modifications of lipid metabolism, lipid peroxidation activity and phospholipase A2, some indicators of endogenous intoxication and hypoxia was held. There were analyzed the results of the treatment of 65 patients with acute peritonitis of an appendiceal genesis. The antihypoxant was included in the complex therapy of the patients of the basic group in the early postoperative period. Preparation application led to fast positive clinical and laboratory dynamics and improved the results of the treatment. The major effect of the antihypoxant was in the reduction of the severity of endogenous intoxication by rising detoxication abilities of an organism and decreasing of membrane destructive processes due to reduction of lipid peroxidation and the hypoxia phenomena.

Keywords: lipid peroxidation, peritonitis, endogenous intoxication, remaxol, antihypoxant