ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Synthesis, structure and biological activity of novel pentacoordinated zvitter-ionic complexes of silicon on the base of α-amino- and α-hydroxyacids
About authors
1 Department of Chemistry, Medical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Department of Microbiology and Virology, Pediatric Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
3 A. N. Nesmeyanov lnstitute of Element Organic Compounds, Moscow, Russia
4 Mendeleyev University of Chemical Technology of Russia, Moscow
Correspondence should be addressed: Vadim Negrebetsky
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.umsr@1ykstebergen
Received: 2012-07-11
Accepted: 2012-10-31
Published online: 2017-01-05
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Eight novel hypercoordinated silicon compounds were synthesized. Their structures were confirmed by multinuclear spectroscopy of nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction study. The prognosis of biological activity indicated that complexes of hypercoordinated silicon could be screened as cardioprotective agents, and drugs for side (lateral) amiotrophic sclerosis treatment based on these complexes could be developed. All studied compounds had low predicted toxicity, which was confirmed by cytotoxicity tests on the model of tissue and bacterial cultures.
Keywords: compounds of hypercoordinated silicon, spectroscopy of nuclear magnetic resonance, Infrared spectroscopy, X-ray analysis, biological activity