ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
The Association of Angiotensin Converting Enzyme Gene Polymorphism with the Development of Carbohydrate Metabolism Disorders
About authors
1 Department of Therapy and Family Medicine, Doctors’ Improvment Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 JSC «Medicine», Moscow, Russia
Correspondence should be addressed: Evgeniy Aksenov
2-y Tverskoy-Yamskoy per., d. 10, Moscow, Russia, 125047; ur.liam@vonexa_e
Received: 2012-10-17
Accepted: 2012-12-19
Published online: 2017-01-05
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The healthy patients (50 women and 42 men) with different genotypes of the angiotensin converting enzyme (ACE) gene were studied. The influence of ACE gene l/D polymorphism on the insulin resistance progression was evaluated. The 5-year probability estimation of carbohydrate metabolism disorders in patients with different ACE gene genotypes was done. It was revealed that the most part of DD genotype patients had a latent hyperinsulinemia. The subjects with II genotype were more resistant to carbohydrate metabolism disorders, rather than DD genotype subjects. It was shown that the risk of all carbohydrate metabolism disorders was 3.9 times higher in DD vs. II genotype groups with a 95 % confidence interval from 1.06 to 14.3 (p = 0.041).
Keywords: risk factors, angiotensin converting enzyme gene polymorphism, insulin resistance