The purpose of the research is to evaluate the effectiveness of an antioxidant therapy on systemic distress damages of oxidative character on the model of an acute destructive pancreatitis. It was studied the functional and metabolic state of the intestine, liver, kidneys in dogs against the antioxidant therapy. The use of the antioxidant emoxipin prevents the excessive activity of lipid peroxidation in blood plasma, tissue structures of the lesion organ (pancreas) and target organs (intestines, liver, kidneys), which determines the restoration of their functional status, preventing the progression of lesions. As a result, the correction of homeostasis disorders takes place, in particular reduction of endogenous intoxication and a decrease of inflammatory process in a pancreas.