Nowadays cardiovascular diseases are the leading reason for mortality and disabling all over the world. One of the groups with initially high cardiovascular risk are patients with HIV infection. In spite of the great amount of investigations conducted to evaluate the metabolic abnormalities in these patients, data on metabolic changes in the natural course of HIV infection with the saved immune system function is not enough. We have investigated 21 patients with the natural course of HIV infection with CD4⁺ cells level over 350 cells/ml. Pro-atherogenic changes in the lipid and carbohydrate profile in comparison with the control group were not found. There was exposed a significantly higher level of tumor necrosis factor a and von Willebrand factor in comparison with the control group. Thus, to determine the total cardiovascular risk beyond traditional risk factors in HIV-infected patients there should be evaluated the levels of inflammation and coagulation markers.