The purpose of the study was to examine gender-specific hormonal profile of CHD patients with metabolic syndrome. There were examined 147 patients with chronic coronary heart disease (mean age 56.9 ± 5.3 years), 63 of them were with metabolic syndrome, 84 — were without it. The control group consisted of 80 healthy volunteers. There were established gender-specific hormonal features of patients with metabolic syndrome, consisting of the higher values of the basal secretion of leptin, insulin, ACTH and cortisol in women. The identified differences may be associated with a greater severity of abdominal obesity in women as the main component of the metabolic syndrome.