In a comparative population-based cross-sectional representative sampling study there was revealed that the prevalence of chronic noncommunicable diseases, regardless of living in the countryside or in the city is associated with a more than two-fold increase of the level of anxiety and depression. The reduction of arterial hypertension, angina pectoris, anxiety and depression prevalence associated with progressive increase of respondents' financial and educational level were specific only for the urban population. These data can be a basis for the development of the targeted integrated prevention programs.