2014 / 01

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ORIGINAL RESEARCH

Prostaglandin E2 Modulating Cholinergic Regulation of Cardiovascular System in Normotensive Animals

Runikhin AYu1, Poryadin GV2, Savchuk VI3
About authors

1 Department of Endocrinology and Diabetology, Faculty of Doctors’ Improvement,
Pirogov Russian National Research Medical University, Moscow, Russia

2 Department of Pathophysiology and Clinical Pathophysiology, Medical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia

3 Institute for Fundamental and Applied Biomedical Research,
Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Vera Savchyuk
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.liam@uanihkinur

Received: 2013-09-02 Accepted: 2014-02-20 Published online: 2017-01-05
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The aim of the study was the evaluation of prostaglandin E2 (PGE2) influence on cholinergic cardiac innervation. Our experimental investigation established that PGE2 induced cardiodepressor effect in normotensive cats (n = 88) due to vagus nerves activation. PGE2 stimulated vagal C-afferent fibers thus leading to vagotonia. Vagotonic effect of PGE2 is one of the mechanisms for myocardium contractility and antihypertensive action. PGE2 modulating cholinergic influence may improve blood pressure control and morphology and function of vital organs.

Keywords: prostaglandin E2, vagus nerve, C-afferent fibers, antihypertensive effect

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