The influence of natural polyphenolic compounds included in a new collection of medicinal plant products on the physical endurance of mice in the re-swim test was studied. It was found out that the course application of aqueous extract from the plant collection in the experimental group of mice did not effect the duration of the primary swim, but increased to 1,7 times the length of re-swimming against the same parameter in the control group (p <0.001). This result demonstrates the positive effect of the proposed plant collection on the recover processes after physical activity, i.e. its actoprotective action. It is assumed that the actoprotective action of the medicinal plant collection is due to antioxidant properties of biologically active substances in its composition.