There was performed the analysis of modern concepts and own experience of the new technologies use in the treatment of gonarthrosis. There are presented the data on the use of platelet-rich plasma (PRP), which is used for the manufacture of whole autologous blood. There are reviewed the mechanisms of PRP action, the results of clinical studies in which there was used autologous conditioned plasma in the treatment of gonarthrosis. It is noted that the method is technically simple and devoid of serious side effects. There are presented the data that the local application of PRP in patients with knee osteoarthrosis produces a strong positive dynamics of the functional state of the knee joints in case of early manifestations of osteoarthritis, but in gonarthrosis of II-III radiographic stages the positive impact of osteoarthrosis is less efficient. It is concluded that there are prospects for further studies of the mechanism of PRP action. It is necessary, in particular, to clarify whether PRP is only the means of symptomatic treatment of osteoarthrosis or it also relates to pathogenetic reasonable methods of treatment of this disease.