Until now strategy of management of incomplete pregnancy with registered absent end diastolic flow (AEDF) in the umbilical artery in the preterm has not been worked out. There were analyzed 29 cases of singleton pregnancy, when AEDF in the umbilical artery was registered at 25–37 weeks of gestation. It was established that in preterm pregnancy and registration of AEDF in the umbilical artery prolongation of pregnancy in order to prevent the development of respiratory distress syndrome of the fetus is possible if cardiomonitoring observation reveals normal heart rate variability, reactive non-stress test and/or normal respiratory movements and normal volume of amniotic fluid. After 34 weeks of gestation with registration of AEDF in the umbilical artery, pregnancy prolongation is inappropriate.