Laryngeal papillomatosis is one of the important and unresolved problems of modern medicine. Tumor affects both children and adults, which is often fraught with serious life-threatening complications to the patient. The aim of the study was to evaluate the effectiveness of treatment of patients with laryngeal papillomatosis by using the combined method — cold plasma endolaryngeal microsurgery papillomas and inducers of an endogenous interferon therapy and activator of NK-killers (trade name Allokin-alpha) compared with the surgery without preventive treatment. The study included 50 patients, divided into two equal groups. In the study group, which consisted of 25 patients who received the combination treatment there increased an interrecurrent period and reduced the frequency of recuring. Thus, this method of treatment is recommended for the laryngeal papillomatosis.