ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Stability of gadolinium-based contrast agents in the presence of zinc and calcium ions in different media
About authors
1 P. V. Sergeev Molecular Pharmacology and Radiobiology Department, Biomedical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Laboratory of Radiotherapy Methods and Technologies Development,A. I. Burnazyan Federal Medical and Biophysical Centre, Moscow, Russia
3 Laboratory of Radionuclide and Radiation Technologies in Experimental Oncology,N. N. Blokhin Russian Cancer Scientific Centre, Moscow, Russia
Correspondence should be addressed: Nikolay Shimanovskii
ul. Bolshaya Pirogovskaya, d. 9A, Moscow, Russia, 119435; ur.xednay@nnnamihs
About paper
Funding: this study was conducted within the framework of a public contract No. 11411.1008700.13.081 under the Federal Targeted Program “Development of Pharmaceutical and Medical Industries of the Russian Federation up to 2020 and beyond” approved by the resolution of the Government of the Russian Federation No. 91 dated 17 February 2011.
Received: 2015-09-29
Accepted: 2015-10-12
Published online: 2017-01-05
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Fig. 1. Effect of zinc ions on Т1 water proton relaxation time in the studied MRCAs solutions in water (pH 6.0)
Here and in fig. 2–5 below: CGP — gadopentetate- β-cyclodextrin .* — statistically significant difference from the control (p < 0.05).
Fig. 2. Effect of zinc ions on T1
Fig. 3. Effect of zinc ions and PVP on Т1
Fig. 4. Effect of zinc ions on Т1
Fig. 5. Effect of zinc ions and PVP on Т1
