ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Stability of gadolinium-based contrast agents in the presence of zinc and calcium ions in different media
About authors
1 P. V. Sergeev Molecular Pharmacology and Radiobiology Department, Biomedical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
2 Laboratory of Radiotherapy Methods and Technologies Development,A. I. Burnazyan Federal Medical and Biophysical Centre, Moscow, Russia
3 Laboratory of Radionuclide and Radiation Technologies in Experimental Oncology,N. N. Blokhin Russian Cancer Scientific Centre, Moscow, Russia
Correspondence should be addressed: Nikolay Shimanovskii
ul. Bolshaya Pirogovskaya, d. 9A, Moscow, Russia, 119435; ur.xednay@nnnamihs
About paper
Funding: this study was conducted within the framework of a public contract No. 11411.1008700.13.081 under the Federal Targeted Program “Development of Pharmaceutical and Medical Industries of the Russian Federation up to 2020 and beyond” approved by the resolution of the Government of the Russian Federation No. 91 dated 17 February 2011.
Received: 2015-09-29
Accepted: 2015-10-12
Published online: 2017-01-05
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To improve the safety of Gd3+-based contrast agents (GBCA) in clinical practice, it is recommended to use the most stable substances and to consider conditions determining their stability. The aim of this study was to compare the stability of GBCAs for magnetic resonance imaging in the presence of zinc and calcium ions and polyvinylpyrrolidone (PVP) in water, phosphate buffer solution and blood serum using proton NMR relaxometry. The study demonstrated that macrocyclic gadobutrol is more stable than all linear contrast agents. The addition of PVP (10 mg/ml) improved the stability of linear GBCAs in phosphate buffer solution and blood serum. Calcium ions have a much weaker destabilizing effect on GBCAs than zinc ions.
Keywords: gadolinium-based magnetic resonance contrast agents, polyvinylpyrrolidone, calcium ions, zinc ions, NMR relaxometry