ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Neurodegenerative changes induced by injection of β-amyloid peptide fragment (25-35) in hippocampus are associated with NGF-signalling activation
About authors
Functional Biochemistry of Nervous System Laboratory,Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
Correspondence should be addressed: Mikhail Stepanichev
ul. Butlerova, d. 5А, Moscow, Russia, 117485; moc.oohay@vehcinapets_liahkim
About paper
Funding: this study was supported by the Russian Foundation for Basic Research (grants no. 13-04-01019a and 16-04-01054a ).
Received: 2016-02-14
Accepted: 2016-02-19
Published online: 2017-01-05
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Fig. 1. Effect of amyloid peptide injection on the lesion size in CA1 hippocampal field of rats. * — p < 0.05 compared to the controls (vehicle injection), # — p <0.05 compared to the group injected with Aβ(35–25); Mann–Whitney test
Fig. 2. Effect of amyloid peptide injection on the lesion size in dentate gyrus of rats
Fig. 3. Effect of amyloid peptide injection on p75NTR receptor expression in the hippocampus of rats
* — p < 0.05 compared to the controls (vehicle injection); Mann–Whitney test.
Fig. 4. Effect of amyloid peptide injection on the amount of NGF in the hippocampus of rats
* — p < 0.05 compared to the controls (vehicle injection), # — p < 0.05 compared to the group injected with Aβ(35–25); Mann–Whitney test.
