A number of studies have shown that a CDH13-encoded T-cadherin protein, which is a receptor for low density lipoproteins and adiponectin, an adipocyte hormone, is associated with atherosclerosis and coronary heart disease (CHD) development. Some single nucleotide polymorphisms in CDH13 gene affect the expression of T-cadherin and the levels of adiponectin and blood plasma lipids, but the connection between these polymorphisms and CHD development has not been studied yet. In this work the role of rs12051272, rs4783244, rs12444338 and rs11646213 single nucleotide polymorphisms in CHD development and its manifestations was investigated. The study enrolled men under 55 years of age: 79 patients with stable effort angina with no prior myocardial infarction, 107 patients with prior myocardial infarction being the first manifestation of CHD, and 99 healthy subjects. All subjects were clinically examined; laboratory tests and genotyping were conducted. The results of genotyping were evaluated using SNPStats on-line software. This study has not found a connection between CDH13 gene polymorphisms and CHD development. However, it was shown that rs12051272 polymorphism is associated with the specifics of the disease onset: GT genotype was detected in 13 (16.5 %) patients with stabile effort angina and only in 3 (2.8 %) patients with myocardial infarction (odd ratio of 7.54; 95 % confidence interval of 2.01–28.35). Thus, the study demonstrates that CDH13 gene polymorphism can affect atherogenesis and CHD manifestations.