2016 / 03

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DOI: 10.24075/brsmu.2016-03-01

REVIEW

Human genome editing

Rebrikov DV1,2,3
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Kulakov Federal Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

3 Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

Correspondence should be addressed: Denis V. Rebrikov
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; moc.liamg@vokirberd

Received: 2016-06-23 Accepted: 2016-06-25 Published online: 2017-01-05
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Fig. 1. Timeline indicating the evolvement of some genome editing systems (Doudna, Charpentier [45])
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Fig. 2. Scheme of genomic editing based on zinc-finger hybrid nucleases, meganucleases, TALE hybrid nucleases and CRISPR/Cas9 (Yin et al., 2014 [47], as amended)
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Fig. 3. Fetal (A) and somatic cell (B) gene therapy algorithms
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Table 1. Composition of the components of the main enzyme of genome editing systems, and some features of the systems
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Table 2. Examples of diseases treated using genomic editing based on designer nucleases
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