ORIGINAL RESEARCH

The efficacy of systemic enzyme therapy in the complex treatment of trophic ulcers of venous etiology

Vasilev IM1,2, Bogdanec LI2, Shcherbin SV3
About authors

1 Research and Education Center for Medical Science and Technology,
Bauman Moscow State Technical University, Moscow, Russia

2 Department of Thoracic Surgery No. 1, Faculty of General Medicine,
Pirogov Russian National Research Medical University, Moscow, Russia

3 Department of Morphology, Faculty of Medicine and Biology,
Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Ivan Vasilev
Leninsky prospekt, d. 10, korp. 5, Moscow, Russia, 117049; ur.liam@savidm

Received: 2016-10-24 Accepted: 2016-10-28 Published online: 2017-01-05
|
  1. Lipnitskiy EM. Lechenie troficheskikh yazv nizhnikh konechnostey. Moscow: Meditsina; 2001. 160 p. Russian.
  2. Saveliev VS, Kirienko AI, Bogachev VYu. [Chronic venous diseases in the Russian Federation. Results of VEIN CONSULT international research program]. Flebologiya. 2010. 4 (3): 9–12. Russian.
  3. Bradbury AW. Epidemiology and aetiology of C4-6 disease. Phlebology. 2010 Oct; 25 Suppl 1: 2–8. DOI: 10.1258/phleb.2010.010s01.
  4. Khanevich MD, Khrupkin VI, Shchelokov AL, Fominykh EM. Oslozhnennye formy khronicheskoy venoznoy nedostatochnosti nizhnikh konechnostey. Moscow: MedEkspertPress; Petrozavodsk: IntelTek; 2003. P. 53–8. Russian.
  5. Kirienko AI. Flebologicheskie problemy klinicheskoy praktiki. Rossiyskie meditsinskie vesti. 2007; 12 (4): 53–6.
  6. Assotsiatsiya flebologov Rossii, Vserossiyskoe obshchestvo khirurgov. Klinicheskie rekomendatsii po diagnostiki i lecheniyu khronicheskikh zabolevaniy ven. Flebologiya. 2009; 3 (3): 75.
  7. Shval'b PG, Gryaznov SV, Shval'b AP. Nekotorye voprosy patogeneza troficheskikh yazv venoznogo proiskhozhdeniya. Angiologiya i sosudistaya khirurgiya. 2005; 11 (1): 61–4. Russian.
  8. Korthuis RJ, Gute DC. Adhesion molecule expression in postischemic microvascular dysfunction: activity of a micronized purified flavonoid fraction. J Vasc Res. 1999; 36 Suppl 1: 15−23.
  9. Lebedev KA, Ponyakina ID, Kozachenko NV. Physiology of chronic inflammatory processes and their treatment. Human Physiology. 2005; 31 (1): 86–97. DOI: 10.1007/s10747-005-0012-5.
  10. Bergan JJ, Pascarella L, Schmid-Schönbein GW. Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension. J Vasc Surg. 2008 Jan; 47 (1): 183–92. DOI: 10.1016/j.jvs.2007.09.028.
  11. Kirienko AI, Ataullakhanov RI, Bogachev VYu, Bogdanets LI, Pichugin AV, Zhuravleva OV. Troficheskie yazvy venoznoy etiologii i ikh svyaz' s immunnym statusom. Angiologiya i sosudistaya khirurgiya. 2007; 13 (1): 76–86. Russian.
  12. Powell CC, Rohrer MJ, Barnard MR, Peyton BD, Furman M, Michelson AD. Chronic venous insufficiency is associated with increased platelet and monocyte activation and aggregation. J Vasc Surg. 1999 Nov; 30 (5): 844–51.
  13. Štvrtinova V, Jahnova E, Weissova S, Horvathova M, Ferenčik M. Expression of adhesion molecules on leukocytes of patients with chronic venous insufficiency. Phlebologie. 2002; 31 (3): 63−8.
  14. Takase S, Bergan JJ, Schmid-Schönbein G. Expression of adhesion molecules and cytokines on saphenous veins in chronic venous insufficiency. Ann Vasc Surg. 2000 Sep; 14 (5): 427–35.
  15. Kirienko AI, Koshkin VM, Bogachev VYu. Sistemnaya enzimoterapiya v angiologii. In: Materialy Vserossiyskoy nauchno-prakticheskoy konferentsii khirurgov. Vserossiyskaya nauchno-prakticheskaya konferentsiya khirurgov; Kaluga, 1997 Sep 26–27. Kaluga; 1996. P. 91. Russian.
  16. Kirienko AI, Koshkin VM, Agafonov VF. Sistemnaya enzimoterapiya posstromboflebeticheskoy bolezni. In: Kriticheskaya ishemiya. Itogi XX veka. Materialy 3-go Mezhdunarodnogo kongressa severnykh stran i regionov; Petrozavodsk–Parizh, 1999. Petrozavodsk; 1999. P. 151. Russian.
  17. ZHeleznikova GF. [Regulatory t cells in immune response to infection]. Journal Infectology. 2011; 3 (1): 6–13. Russian.
  18. Masopust D, Vezys V, Marzo AL, Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science. 2001 Mar 23; 291 (5512): 2413−7.