2017 / 02

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DOI: 10.24075/brsmu.2017-02-06

ORIGINAL RESEARCH

Normal vaginal microbiota: patient’s subjective evaluation, physical examination and laboratory tests

Voroshilina ES1,2, Zornikov DL1, Plotko EE2,3
About authors

1 Department of Microbiology, Virology and Immunology, Faculty of Preventive Medicine,
Ural State Medical University, Yekaterinburg, Russia

2 Harmony Medical and Pharmaceutical Center, Yekaterinburg, Russia

3 Department of Obstetrics and Gynecology, Faculty of Medicine and Healthcare,
Ural State Medical University, Yekaterinburg, Russia

Correspondence should be addressed: Еkaterina S. Voroshilina
ul. Furmanova, d. 30, Yekaterinburg, Russia, 620142; moc.liamg@anilihsorov

About paper

Acknowledgements: the authors wish to thank Director of Harmony Medical and Pharmaceutical Center, Yekaterinburg, for the opportunity to conduct the study at the facilities of the Center.

Contribution of the authors to this work: Voroshilina ES and Zornikov DL — analysis of literature, research planning, data collection, analysis, and interpretation, drafting of a manuscript; Plotko EE — data analysis and interpretation, drafting of a manuscript. All authors participated in editing of the manuscript.

Received: 2017-04-11 Accepted: 2017-04-20 Published online: 2017-05-31
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  1. Grice EA, Segre JA. The human microbiome: our second genome. Annu Rev Genomics Hum Genet. 2012; 13: 151–70. DOI: 10.1146/annurev-genom-090711-163814.
  2. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13; 486 (7402): 207–14. DOI: 10.1038/nature11234.
  3. Macklaim JM, Fernandes AD, Di Bella JM, Hammond JA, Reid G, Gloor GB. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome. 2013 Apr 12; 1 (1): 12. DOI: 10.1186/2049-2618-1-12.
  4. Macklaim JM, Gloor GB, Anukam KC, Cribby S, Reid G. At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1: 4688–95. DOI: 10.1073/pnas.1000086107.
  5. Ravel J, Brotman RM, Gajer P, Ma B, Nandy M, Fadrosh DW, et al. Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis. Microbiome. 2013 Dec 2; 1 (1): 29. DOI: 10.1186/2049-2618-1-29.
  6. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1: 4680–7. DOI: 10.1073/pnas.1002611107.
  7. Donnarumma G, Molinaro A, Cimini D, De Castro C, Valli V, De Gregorio V, et al. Lactobacillus crispatus L1: high cell density cultivation and exopolysaccharide structure characterization to highlight potentially beneficial effects against vaginal pathogens. BMC Microbiol. 2014 May 30; 14: 137. DOI: 10.1186/1471- 2180-14-137.
  8. McLean NW. Rosenstein IJ. Characterisation and selection of a Lactobacillus species to re-colonise the vagina of women with recurrent bacterial vaginosis. J Med Microbiol. 2000; 49 (6): 543– 52. DOI: 10.1099/0022-1317-49-6-543.
  9. Voroshilina ES, Tumbinskaya LV, Donnikov AE, Plotko EA, Khayutin LV. [Vaginal biocenosis with a view to quantitative polymerase chain reaction: what is its norm?] Obstetrics and Gynecology. 2011; (1): 57–65. Russian.
  10. Kira EF. Bakterial'nyj vaginoz. Sankt-Peterburg: Neva-Lyuks; 2001. 364 p. Russian.