ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2017 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Analysis of VEGF circulating RNA isoforms in patients with breast cancer
About authors
1 Laboratory for Genome Editing,Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
2 Department of Anatomic Pathology,Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
3 Department of Breast Pathology,Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Correspondence should be addressed: Denis V. Rebrikov
ul. Oparina, d. 4, Moscow, Russia, 117997; moc.liamg@vokirberd
About paper
Acknowledgements: the authors thank Olga Burmenskaya (Department of Clinical and Molecular Genetics of Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia) for participating in the discussion of the study results.
All authors' contribution to this work is equal: selection and analysis of literature, research planning, data collection, analysis, and interpretation, drafting of a manuscript, editing.
Received: 2017-08-15
Accepted: 2017-08-25
Published online: 2017-10-30
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The present study aims to estimate and compare the levels of cell-free circulating RNAs of three interleukins IL-6, IL-8, and IL-18 and three splice variants of the vascular endothelial growth factor (VEGF), namely 121, 165 and 189, in blood plasma of patients with stage I / II breast cancer and healthy controls. The study reveals that patients with breast cancer have significantly elevated levels of circulating VEGF121 and VEGF165 RNAs, so far unreported in the literature. We also confirm that levels of circulating IL-8 and IL-18 RNAs are considerably increased in breast cancer patients.
Keywords: cytokines, breast cancer, circulating RNA, VEGF isoform, qPCR