This work aims to study distribution of allele frequencies of the ACE and BDKRB2 genes coding for the angiotensin-converting enzyme and the bradykinin receptor β2, respectively, in athletes specializing in different sports and to establish the associations between the studied genotypes and heart rate variability. The study included 75 male athletes. Polymorphisms of ACE and BDKRB2 (I/D and +9/−9, respectively) were studied by PCR. A significant difference was revealed in the −9/−9 genotype frequency between the studied groups of athletes. Parasympathetic nerve activity prevailed in the athletes with the I allele of the ACE gene. Time-domain parameters of heart rate variability had low values in the carriers of the D/D genotype. In the athletes with the ACE I/I genotype the time-domain parameters differed from those typical for the I/D and D/D genotype carriers. Participants homozygous for −9 BDKRB2 had the lowest heart rate in the studied sample, implying an increased contribution of parasympathetic activity to heart rate regulation. The −9 allele of BDKRB2 was found to be associated with the minimal R — R interval between consecutive hear beats. We conclude that polymorphisms I/D of ACE and +9/−9 of BDKRB2 can indicate individual patterns of heart rate regulation in athletes from the Republic of Karelia.