ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Adaptive immunity and genetic aspects of tuberculosis in children
About authors
Department of Pediatrics, Center of Continuing Professional Education and Retraining,Omsk State Medical University, Omsk, Russia
Correspondence should be addressed: Maria Plekhanova
ul. Lenina, d. 12, Omsk, Russia, 644099; ur.liam@sulp-anid
About paper
Funding: this work was supported by the Russian Foundation for Basic Research (Grant ID 16-16-55001).
Received: 2017-09-24
Accepted: 2017-10-25
Published online: 2018-01-13
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Table 1. Results of clinical and laboratory examinations/tests of children from TB and LTB groups
Table 2. Results of immunoassay of blood of children from TB, LTB and NTB groups
Note. * — p < 0.05 when comparing results in TB and LTB groups (Mann–Whitney test, U); ** — p < 0.05 when comparing results in TB and NTB groups (Mann– Whitney test, U); *** — p < 0.05 when comparing results in LTB and NTB groups (the Mann–Whitney test, U).
Table 3. Level of interferon gamma synthesis induced by specific antigens, depending on the genotype (polymorphic variant rs2069705 (T-1488C) of IFNG gene) in TB group children
Table 4. Frequency of negative reactions to specific antigens depending on genotype (polymorphic variant rs2069705 (T-1488C) of IFNG gene) in TB group children
