ORIGINAL RESEARCH
The role of immunological memory in establishing antitumor immunity in patients with ovarian cancer undergoing neoadjuvant therapy
1 Laboratory for Immunophenotyping of Tumors,Rostov Research Institute of Oncology, Rostov-on-Don, Russia
2 Department of Gynecologic Oncology,Rostov Research Institute of Oncology, Rostov-on-Don, Russia
Correspondence should be addressed: Elena Zlatnik
14-ya liniya, d. 63, Rostov-on-Don, Russia, 344037; ur.liam@kintalz-anele
Contribution of the authors to this work: Zlatnik EYu — processing and analysis of results of immunological tests, drafting of a manuscript, correspondence with editors; Nerodo GA — research planning, medical supervision, surgical operations and treatment of the patients, data analysis and interpretation; Ardzha AYu — analysis of literature, data collection and analysis, medical supervision; Seliutina ON, Bondarenko ES — immunological tests.
- Cannon MJ, O'Brien TJ. Cellular immunotherapy for ovarian cancer. Expert Opin Biol Ther. 2009 Jun; 9 (6): 677–88. DOI: 10.1517/14712590902932897.
- Golubovskaya V, Wu L. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy. Cancers (Basel). 2016 Mar 15; 8 (3): pii: E36. DOI: 10.3390/cancers8030036.
- Beckhove Ph, Feuerer M, Dolenc M, Schuetz F, Choi C, Sommerfeldt N, et al. Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors. J Clin Invest. 2004 Jul 1; 114 (1): 67–76. DOI: 10.1172/JCI200420278.
- Dunbar PR, Smith CL, Chao D, Salio M, Shepherd D, Mirza F, et al. A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response. J Immunol. 2000 Dec 1; 165 (11): 6644–52. DOI: 10.4049/jimmunol.165.11.6644.
- Valmori D, Scheibenbogen C, Dutoit V, Nagorsen D, Asemissen AM, Rubio-Godoy V, et al. Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity. Cancer Res. 2002 Mar 15; 62 (6): 1743–50.
- Hadrup S, Donia M, Thor Straten P. Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment. Cancer Microenviron. 2013 Aug; 6 (2): 123–33. DOI: 10.1007/s12307-012-0127-6.
- Klebanoff CA, Gattinoni L, Torabi-Parizi P, Kerstann K, Cardones AR, Finkelstein SE, et al. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A. 2005 Jul 5; 102 (27): 9571–6.
- Weninger W, Crowley MA, Manjunath N, von Andrian UH. Migratory properties of naive, effector, and memory CD8 (+) T cells. J Exp Med. 2001 Oct 1; 194 (7): 953–66.
- Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003 Mar; 4 (3): 225–34.
- Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999 Oct 14; 401 (6754): 708–12.
- Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004; 22: 745–63.
- Church SE, Jensen SM, Antony PA, Restifo NP, Fox BA. Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells. Eur J Immunol. 2014 Jan; 44 (1): 69–79. DOI: 10.1002/eji.201343718.
- Perret R, Ronchese F. Memory T cells in cancer immunotherapy: which CD8 T-cell population provides the best protection against tumours? Tissue Antigens. 2008 Sep; 72 (3): 187–94. DOI: 10.1111/j.1399-0039.2008.01088.x.
- Shin H, Iwasaki A. Tissue-resident memory T cells. Immunol Rev. 2013 Sep; 255 (1): 165–81. DOI: 10.1111/imr.12087.
- Zammit DJ, Turner DL, Klonowski KD, Lefrançois L, Cauley LS. Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity. 2006 Apr; 24 (4): 439–49.
- Shin H, Iwasaki A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature. 2012 Nov 15; 491 (7424): 463–7. DOI: 10.1038/nature11522.
- Mackay LK, Stock AT, Ma JZ, Jones CM, Kent SJ, Mueller SN, et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc Natl Acad Sci U S A. 2012 May 1; 109 (18): 7037–42. DOI: 10.1073/pnas.1202288109.
- Preston CC, Goode EL, Hartmann LC, Kalli KR, Knutson KL. Immunity and immune suppression in human ovarian cancer. Immunotherapy. 2011 Apr; 3 (4): 539–56. DOI: 10.2217/imt.11.20.
- de Bruyn M, Wiersma VR, Wouters MC, Samplonius DF, Klip HG, Helfrich W, et al. CD20+ T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer. Oncoimmunology. 2015 Mar 19; 4 (4): e999536. eCollection 2015 Apr. DOI: 10.1080/2162402X.2014.999536.
- Balkwill F. Cancer and the chemokine network. Nat Rev Cancer. 2004 Jul; 4 (7): 540–50. DOI: 10.1038/nrc1388.
- Berezhnaya NM, Chekhun VF. Immunologiya zlokachestvennogo rosta. Kiev: Naukova Dumka; 2005. 792 p. Russian.
- Fidler IJ. The organ microenvironvent and cancer metastasis. Differentiation. 2002 Dec; 70 (9–10): 498–505.
- Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvirontments. Cancer Res. 2006 Jan 15; 66 (2): 605–12.
- Ashrafyan LA, Kiselev VI, Muizhnek EL, Gerfanova EV, Antonova IB, Kuznetsov IN, et al. [Current principles of effective therapy for ovarian cancer.] Opukholi zhenskoy reproduktivnoy sistemy. 2015; 11 (2): 68–75. Russian.
- Tyulyandin SA, Den'gina NV, Kolomiets LA, Morkhov KYu, Nechushkina VM, Pokataev IA, et al. Prakticheskie rekomendatsii po lekarstvennomu lecheniyu raka yaichnikov/ pervichnogo raka bryushiny/ raka matochnykh trub. Zlokachestvennye opukholi. 2016; (4 Suppl 2): 123–34. Russian.
- Shmelev VA, Lichinitser MR, Abramov ME, Kuznetsov VV, Slavina EG, Kadagidze ZG. Innovatsionnyy protivoopukholevyy tsitokinovyy preparat Ingaron. Meditsinskiy alfavit. Diagnosticheskaya radiologiya i onkoterapiya. 2013; (3–4): 60–8. Russian.
- Nerodo GA, Novikova IA, Zlatnik EYu, Ardzha AYu. [Application of Ingaron in combination with chemotherapy in patients with stage III–IV ovarian cancer]. Fundamental'nye issledovaniya. 2015; (1–8): 1649–54. Russian.
- Bryuzgin VV, Platinskij LV. [The role of cytokines in the chemotherapy of malignant tumors: the practice of cytokines Refnot and Ingaron administration in advanced cancer with multiple metastases]. Sovremennaya onkologiya. 2014; 16 (1): 70–5. Russian.
- Zlatnik EYu, Nerodo GA, Novikova IA, Bakhtin AV, Zakora GI, Selyutina ON, et al. [Molecular and cellular factors of local immunity in ascitic fluid of ovarian cancer patients]. Molekulyarnaya meditsina. 2016; 14 (3): 39–42. Russian.
- Pollard JW. Tumor-educated macrophages promote tumor progression and metastasis. Nat Rev Cancer. 2004 Jan; 4 (1): 71–8.
- Kurganova EV, Tikhonova MA, Lebedeva VA, Laskavaya EG, Kovalenko VF, Ostanin AA, et al. [Regulatory T-cells in ovarian cancer]. Sibirskiy onkologicheskiy zhurnal. 2008; 30 (6): 40–5. Russian.
- Laskavaya EG, Lebedeva VA, Narov YuI, Tikhonova MA, Kurganova EV, Ostanin AA, et al. Regulyatornye CD4+ i CD8+ kletki u bol'nykh s dobrokachestvennymi i zlokachestvennymi obrazovaniyami yaichnikov. Sibirskiy onkologicheskiy zhurnal. 2010; (Suppl 1): 67–8. Russian.
- Chu T, Tyznik AJ, Roepke S, Berkley AM, Woodward-Davis A, Pattacini L, et al. Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep. 2013 Mar 28; 3 (3): 701–8. doi: 10.1016/j.celrep.2013.02.020
- Pagès F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med. 2005 Dec 22; 353 (25): 2654–66.
- Motz GT, Santoro SP, Wang LP, Garrabrant T, Lastra RR, Hagemann IS, et al. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat Med. 2014 Jun; 20 (6): 607–15. DOI: 10.1038/nm.3541.
- Nerodo GA, Zlatnik EYu, Novikova IA, Bakhtin AV, Zakora GI, Ardzha AYu, et al. Pokazateli kletochnogo immuniteta pri primenenii ingarona v kachestve terapii soprovozhdeniya pri rake yaichnikov. Rossiyskiy immunologicheskiy zhurnal. 2015; 1 (1): 141. Russian.
- Roberts AD, Ely KH, Woodland DL. Differential contributions of central and effector memory T cells to recall responses. J Exp Med. 2005 Jul 4; 202 (1): 123–33.