2017 / 06

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DOI: 10.24075/brsmu.2017-06-09

ORIGINAL RESEARCH

Breast cancer: analysis of driver somatic mutations detected by next-generation sequencing

Tsukanov KYu1, Krasnenko AYu1, Korostin DO1, Churov AV2, Stetsenko IF1, Plotnikov NA1, Zarubina SA3, Belova VA3, Kovyrshina AV3, Vorotnikov IK4, Mescheryakov AA4, Ilinsky VV1,3,5
About authors

1 Genotek Inc., Moscow

2 Karelian Research Centre of the Russian Academy of Sciences, Petrozavodsk, Russia

3 Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

4 Blokhin National Medical Research Center of Oncology, Moscow, Russia

5 Institute of Biomedical Chemistry (IBMC), Moscow, Russia

Correspondence should be addressed: Valery Ilyinsky
Nastavnichesky per., d. 17, str. 1, pod. 14, 15, Moscow, 105120; ur.ketoneg@ofni

About paper

Funding: this work was supported by the Ministry of Education and Science of the Russian Federation (Project ID RFMEFI60716X0152).

All authors' contribution to this work is equal: selection and analysis of literature, research planning, data collection, analysis, and interpretation, drafting of a manuscript, editing.

Received: 2017-12-12 Accepted: 2017-12-22 Published online: 2018-01-24
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Distribution of mutation frequencies in the genes ATM, TP53 and BRCA1 in patients with beast cancer
Table 1. Clinicopathologic features of patients with breast cancer (n = 16)
Table 2. Single nucleotide variants (mutations) identified in patients with breast cancer (n = 16)