ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2018 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
REVIEW
Mycobacterium tuberculosis: drug resistance, virulence and possible solutions
About authors
1 Laboratory of Bacterial Genetics, Department of Genetics and Biotechnology, Vavilov Institute of General Genetics of RAS, Moscow
2 Scientific Research Center for Biotechnology of Antibiotics "BIOAN", Moscow
3 Laboratory of Immunoglobulin Biosynthesis, Mechnikov Research Institute of Vaccine and Sera, Moscow
Correspondence should be addressed: Valery N. Danilenko
Gubkina 3, Moscow, 119991; ur.ggiv@direlav
About paper
Funding: this work was supported by the Project of the Ministry of Education and Science of the Russian Federation "The role of region-specific polymorphisms of virulence genes in the formation of drug resistance of Mycobacterium tuberculosis" (Project ID RFMEFI61317X0068).
Received: 2018-06-05
Accepted: 2018-07-10
Published online: 2018-08-23
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Fig. 1. Evolution of the Beijing lineages. Wide use of antibiotics in the recent decades has provided selective advantage to the B0/W-14 strain characterized by a high
level of drug resistance
