Bulletin of RSMU

ORIGINAL RESEARCH

Quantification of fetal DNA in the plasma of pregnant women using next generation sequencing of frequent single nucleotide polymorphisms

Shubina J^1,2, Jankevic T², Goltsov AYu², Mukosey IS, Kochetkova TO, Bystritsky AA, Barkov IYu, Tetruashvili NK, Kim LV, Trofimov DYu²

About authors

¹ Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

² DNA-Technology LLC, Moscow, Russia

Correspondence should be addressed: Jekaterina Shubina
Akademika Oparina 4, Moscow, 117997; moc.liamg@anibuhs.aniretakej

About paper

Funding: this work was supported by the Ministry of Education and Science of the Russian Federation (Agreement 14.607.21.0136, Project ID RFMEFI60715X0136).

Received: 2018-04-15 Accepted: 2018-04-18 Published online: 2018-08-11

Fig. 1. Comparison of the estimates of the fetal DNA fragment fraction done by targeted SNP sequencing and Y chromosome read count

Table 1. Data generated by the sequencing of pooled samples

Table 2. Comparison of SNP frequencies in the pooled samples and 87 individual samples

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ORIGINAL RESEARCH Quantification of fetal DNA in the plasma of pregnant women using next generation sequencing of frequent single nucleotide polymorphisms

Shubina J, Jankevic T, Goltsov AYu, Mukosey IS, Kochetkova TO, Bystritsky AA, Barkov IYu, Tetruashvili NK, Kim LV, Trofimov DYu

Published in "Bulletin of RSMU" 3, 2018

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Vancouver style

Shubina J, Jankevic T, Goltsov AY, Mukosey IS, Kochetkova TO, Bystritsky AA, et al. Quantification of fetal DNA in the plasma of pregnant women using next generation sequencing of frequent single nucleotide polymorphisms. Bulletin of RSMU. 2018; (3): 29–33. DOI: 10.24075/brsmu.2018.031

Harvard style

Shubina, J., Jankevic, T., Goltsov, A. Y., Mukosey, I. S., Kochetkova, T. O., Bystritsky, A. A., et al. (2018), "Quantification of fetal DNA in the plasma of pregnant women using next generation sequencing of frequent single nucleotide polymorphisms", Bulletin of RSMU, no. 3, p. 29–33. DOI: 10.24075/brsmu.2018.031

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ORIGINAL RESEARCH

Quantification of fetal DNA in the plasma of pregnant women using next generation sequencing of frequent single nucleotide polymorphisms