2018 / 04

Next Paper
DOI: 10.24075/brsmu.2018.051

ORIGINAL RESEARCH

Parameters of vancomycin pharmacokinetics in postoperative patients with renal dysfunction: comparing the results of a pharmacokinetic study and mathematical modeling

Ramenskaya GV1, Shokhin IE1,3, Lukina MV2, Andrushishina TB2, Chukina MA2, Tsarev IL2, Vartanova OA2, Morozova TE2
About authors

1 Department of Pharmaceutical and Toxicological Chemistry, Institute of Pharmacy,
Sechenov First Moscow State Medical University (Sechenov University), Moscow

2 Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Faculty of General Medicine,
Sechenov First Moscow State Medical University (Sechenov University), Moscow

3 Center of Pharmaceutical Analytics Ltd., Moscow

Correspondence should be addressed: Maria V. Lukina
Bolshaya Pirogovskaya, 2 bl.4, Moscow, 119435; ur.xednay@0102kul-iram

About paper

Acknowledgements: the authors wish to thank Oleg V. Babenko, Chief Physician of the University Clinical Hospital No.1 of Sechenov First Moscow State Medical University for providing an opportunity to carry out our research

Received: 2018-05-16 Accepted: 2018-08-25 Published online: 2018-10-11
|
Fig. 1. The range of AUC24 values obtained through MM and high-performance liquid chromatography in postoperative patients with acute kidney injury 48 hours after the onset of therapy and upon its completion
Fig. 2. Dependency of AUC241 on the levels of steady-state Ctrough1 48 hours after the onset of antibacterial treatment (HPLC)
Fig. 3. Dependency of AUC242 on the levels of steady-state Ctrough2 at the time of therapy completion (HLPC)
Table 1. Clinical characteristics of patients included in the study
Note: * significant differences, рvalue < 0.05; BMI — body mass index; ClCr — creatinine clearance rate (Cockroft–Gault equation); ClCr 0 — before the surgery; ClCr 1 — 2–3 days after the surgery; ClCr 2 — 7–10 days after the surgery; MV — mechanical ventilation; EF — ejection fraction.
Table 2. Vancomycin pharmacokinetics evaluated by HPLC and MM in the groups of patients with and without AKI 48 h after the onset of therapy and at the time of its completion
Note: 1 — 48 h after the onset of therapy; 2 — at the time of its completion.
Table 3. Prediction of the AUC24/MIC ratio for Staphylococcus aureus 48 hours after the onset of vancomycin therapy
Table 4. Prediction of the AUC24/MIC ratio for Staphylococcus aureus at the time of vancomycin therapy completion