2018 / 05

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DOI: 10.24075/brsmu.2018.071

ORIGINAL RESEARCH

Synthesis of Au (III) polyacrylates and study of their tumoricidal activity

Shibaeva AV1, Pozdniakova NV2, Spiridonov VV3, Smirnova MS4, Korman DB1, Ostrovskaya LA1, Abzaeva KA5, Belyakova AV1,6, Biryukova YuK1,6, Zylkova MV1, Ivanov KP7, Shevelev AB4, Kuzmin VA1
About authors

1 Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia

2 Blokhin National Medical Research Center of Oncology, Moscow

3 Lomonosov Moscow State University, Moscow

4 Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

5 Favorsky Irkutsk Institute of Chemistry, Irkutsk

6 Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow

7 National Medical Research Center for Cardiology, Moscow, Russia

Correspondence should be addressed: Alexei B. Shevelev
Gubkina 3, Moscow, 119991; moc.liamtoh@a_levehs

About paper

Funding: the study was supported by the Ministry of Science and Higher Education of the Russian Federation (Subsidy Contract 14.607.21.0199 dated 26.09.2017, Project ID RFMEFI60717X0199). Spectroscopy was performed at the Shared Research Facility of Favorsky Irkutsk Institute of Chemistry, RAS.

Received: 2018-09-28 Accepted: 2018-10-26 Published online: 2018-12-16
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Fig. 1. The graph shows a correlation between the Au (III) concentration in the tested aurumacryl samples and their cytotoxicity against human breast carcinoma cells (MCF-7). Concentrations at А226.5 expressed as mU are plotted on the X axis. The proportion of the surviving cells measured by the MTT assay is plotted on the Y axis. The curves were constructed for samples 3, 10 and 17 synthesized in the course of this work and for the control sample synthesized at Irkutsk Institute of Chemistry (see Table 1).
Table 1. Synthesis conditions, physical, chemical and biological properties of aurumacryl samples
Note: Freeze-dried samples dissolved in water are shown in grey; other samples were not lyophilized but stored as solutions instead.
Table 2. Distribution of gold nanoparticle sizes in aurumacryl samples synthesized from PAA and PANa