2018 / 06

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DOI: 10.24075/brsmu.2018.073

ORIGINAL RESEARCH

ZAIS-based colloidal QDs as fluorescent labels for theranostics: physical properties, biodistribution and biocompatibility

Istomina MS1,2, Pechnikova NA3,4, Korolev DV, Pochkayeva EI, Mazing DS2, Galagudza MM5, Moshnikov VA2, Shlyakhto EV
About authors

1 Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Peterburg, Russia

2 Department of Micro- and Nanoelectronics, St. Petersburg State Electrotechnical University “LETI”, St. Petersburg

3 Center of Experimental Pharmacology, St. Petersburg State Chemical Pharmaceutical Academy, St. Petersburg

4 Zoological Institute of Russian Academy of Sciences, St. Petersburg

5 Department of Pathophysiology, Pavlov First St. Petersburg State Medical University, St. Petersburg

Correspondence should be addressed: Maria S. Istomina
Parkhomenko 15 B, St. Petersburg, 194156; ur.liam@3991smanimotsi

Received: 2018-07-28 Accepted: 2018-08-23 Published online: 2018-12-24
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Fig. 1. Histogram of the diameter distribution of the ZAIS QDs obtained in the dynamic light scattering study
Fig. 2. Absorption and photoluminescence spectra of ZAIS nanocrystals in distilled water
Fig. 3. Visualization of the intensity of fluorescent radiation in the rat organs at 1 hour (A) and 24 hours (B) after the ZAIS QDs administration
Fig. 4. Animal body weight in the animals 15 days after QDs administration (A) and 30 days after QDs administration (B)
Fig. 5. Results of the research of hematological parameters in the control and at 15 and 30 days after QDs intravenous administration at various doses
Table. Groups of animals and concentrations of injectants for the study of QDs biocompatibility