ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Experimental study of dendrimer-based nanoparticles with RGD-peptide for anticancer radionuclide therapy
About authors
1 Blokhin National Medical Research Center of Oncology, Moscow
2 Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
3 The Loginov Moscow Clinical Scientific Center, Moscow, Russia
4 Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow
Correspondеnce should be adressed: Elena Yu. Grigorieva
Kashirskoe shosse, 24, Moscow, 115478;
ur.liam@11nele-girg
Received: 2018-09-12
Accepted: 2018-10-11
Published online: 2018-12-31
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Fig. 1. The nanoplatform based on the dendrimer conjugated to the RGD peptide
Fig. 2. Dynamics of 188Re-NP and 188Re accumulation (% of the injected amount per 1 g of tissue) in the subcutaneously transplanted LLC1male in male С57Bl/6 mice
Fig. 3. The growth dynamics of the subcutaneously transplanted LLC1 tumor in С57Bl/6 mice following a single injection of 188Re-NP taken at different 188Re doses (А) and a single injection of 188Re sodium perrhenate and 188Re -NP (188Re dose = 185 MBq/kg) (B)
Table 1. Dynamics of 188Re-NP and 188Re accumulation in the organs and tissues of mice with subcutaneously transplanted LLC1 cells (expressed as % from the injected amount per 1 g of the organ/tissue)
Table 2. Comparison of tumor-to-normal uptake ratio of 188Re-NP and 188Re by the organs and tissues of experimental mice
Table 3. The therapeutic effect of the 188Re-NP against the LLC1 carcinoma
Note: The table shows the results of therapeutic efficacy assessment on days 7, 14 and 18 after drug administration.
