ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2019 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
A correlation between the fluctuations of cytokine concentrations measured in the morning and evening and the circadian blood pressure rhythm in patients with stage II essential hypertension
About authors
1 National Research Mordovia State University, Saransk, Russia
2 State Research Institute of Highly Pure Biopreparations, FMBA, St. Petersburg, Russia
3 Mordovian Republican Clinical Hospital No.4, Saransk, Russia
Correspondence should be addressed: Olga A. Radaeva
Ulianova 26/a, Saransk, 430030; ur.liam@97_fybwbltv
About paper
Author contribution: Radaeva OA recruited the study participants, collected blood samples, interpreted the results, analyzed the literature, and helped to write a draft of the manuscript. Simbirtsev AS supervised the research group, identified the aims and objectives of the study, proposed a methodology, and provided critical feedback. Khovryakov AV recruited the study participants, collected blood samples and wrote the manuscript.
Received: 2018-07-16
Accepted: 2019-03-01
Published online: 2019-03-12
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Table 1. Morning and evening concentrations of cytokines (pg/ml) in the serum samples of patients with stage II EH (duration of 10 to 14 years, no antihypertensive
treatment applied)
Note: significance of differences: ' — < 0.05, ^ — < 0.01, * — < 0.001 (comparison with the specified group). The data are presented as an arithmetic mean (M) and a standard deviation (SD).
Table 2. The relationships between morning and evening concentrations of cytokines (pg/ml) in the serum samples of patients with stage II EH (duration of 10 to
14 years, no antihypertensive treatment applied) AND the blood pressure phenotype
Note: significance of differences: ' — < 0.05, ^ — < 0.01, * — < 0.001 (comparison with the specified group); 1 — 7:00 a.m., dippers, 2 — 8:00 p.m, dippers, 3 — 7:00 a.m., non-dippers, 4 — 8:00 p.m., non-dippers, 5 — 7:00 a.m., night-peakers, 6 — 8:00 p.m, night-peakers. The data are presented as a median (Ме) and an interquartile range [С25-С75].
