2019 / 01

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DOI: 10.24075/brsmu.2019.010

ORIGINAL RESEARCH

Injectable collagen in correction of age-related skin changes: experimental and clinical parallels

Manturova NE1, Stenko AG2, Petinati YaA3, Chaikovskaya EA2, Bolgarina AA4
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Institute of plastic surgery and cosmetology, Moscow, Russia

3 Izmerov Research Institute of Occupational Health, Moscow, Russia

4 LLC Nearmedic PLUS, Moscow, Russia

Correspondence should be addressed: Ekaterina A. Chaikovskaya
Olkhovskaya, 27, Moscow, 105066; ur.xednay@ayaksvokiahctk

About paper

Acknowledgements: the authors would like to thank “Nearmedic Plus” (Moscow) for the support of the clinical observational study, as well as Natalya Indilova, Galina Sofinskaya, Evgenia Ikonnikova, medical researchers of the Institute of Plastic Surgery and Cosmetology, and Olga Bondareva and Olesya Sidorova, doctors with Cosmoprodtest SPC, for the assistance they provided in the context of this study.

Author contribution: Manturova NE — research planning and data interpretation; Stenko AG, Petinati YaA — selection of participants, conducting research, data interpretation; Chaikovskaya EA — research planning, data collection and interpretation, manuscript preparation; Bolgarina AA — literature analysis, research planning.

Received: 2018-09-27 Accepted: 2019-02-25 Published online: 2019-03-10
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Fig. 1. Wrinkle visibility change dynamics by face zones (screening data compared to post-course data)
Fig. 2. Dynamics of alteration of skin structure indicators, US scans (post-course median against screening data)
Fig. 3. US scans of forehead skin: screening (A), post-course (B)
Fig. 4. Injection course efficacy assessment, GAIS, applied by participants and medical researchers
Table 1. Skin quality indicators, screening and post-course (p < 0.05)
Note: * — this Table and Table 2 provide median values, brackets contain values of 25th and 75th percentiles.
Table 2. Structural and functional skin indicators, screening and post-course (p < 0.05)